Iodine Deficiency in Egyptian Autistic Children and Their Mothers: Relation to Disease Severity

Traduction partielle : G.M.

Arch Med Res. 2013 Oct 9. pii: S0188-4409(13)00222-1. doi: 10.1016/j.arcmed.2013.09.012.

Carence en iode chez les enfants égyptiens avec autisme et chez les mères : relation avec le trouble

Hamza RT, Hewedi DH, Sallam MT.

Source

Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: rashatarif_2000@hotmail.com

Abstract

BACKGROUND AND AIMS:

Because autism may be a disease of early fetal brain development, maternal hypothyroxinemia (HT) in early pregnancy secondary to iodine deficiency (ID) may be related to etiology of autism.  
Le but de l'étude était d'évaluer l'état nutritionnel en iode chez les enfants autistes égyptiens et de leurs mères et de sa relation avec les caractéristiques du trouble.

METHODS:

Fifty autistic children and their mothers were studied in comparison to 50 controls. All subjects were subjected to clinical evaluation, measurement of urinary iodine (UI), free triiodothyronine (fT₃), free tetraiodothyronine (fT₄) and thyroid-stimulating hormone (TSH) along with measurement of thyroid volume (TV). In addition, electroencephalography (EEG) and intelligence quotient (IQ) assessment were done for all autistic children.

RESULTS:

Parmi les enfants autistes et leurs mères, 54% et 58%, respectivement, étaient carencés en iode. Aucun des enfants témoins ou leur mère n'était carencés en iode.

UI was lower among autistic patients (p <0.001) and their mothers (p <0.001). Childhood Autism Rating Scale (CARS) score correlated negatively with UI (r = -0.94, p <0.001). Positive correlations were detected between autistic patients and their mothers regarding UI (r = 0.88, p <0.001), fT₃ (r = 0.79, p = 0.03), fT₄ (r = 0.91, p <0.001) and TSH (r = 0.69, p = 0.04). Autism had a significant risk for association with each of low UI (OR: 9.5, 95% CI: 2.15-33.8, p = 0.02) and intake of noniodized salt (OR: 6.82, 95% CI = 1.36-34.27, p = 0.031).

CONCLUSIONS:

La carence en iode est fréquente chez les enfants autistes et leurs mères égyptiennes et était inversement proportionnelle à la gravité de la maladie et pourrait être liée à son étiologie.

PMID: 24120386