Évaluation des effets du genre et de l'âge sur les niveaux d'oligoéléments sériques et capillaires chez les enfants avec un diagnostic de "trouble du spectre de l'autisme"

Traduction: G.M.

Metab Brain Dis. 2017 Jun 29. doi: 10.1007/s11011-017-0056-7.

Assessment of gender and age effects on serum and hair trace element levels in children with autism spectrum disorder

Skalny AV^1,2,3,4, Simashkova NV⁵, Skalnaya AA⁶, Klyushnik TP⁵, Bjørklund G⁷, Skalnaya MG¹, Tinkov AA^8,9,10.

Author information

1

RUDN University, Moscow, Russia.

2

Orenburg State University, Orenburg, Russia.

3

Yaroslavl State University, Sovetskaya St., 15, 150000, Yaroslavl, Russia.

4

Trace Element Institute for UNESCO, Lyon, France.

5

Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia.

6

Lomonosov Moscow State University, Moscow, Russia.

7

Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.

8

RUDN University, Moscow, Russia. tinkov.a.a@gmail.com.

9

Yaroslavl State University, Sovetskaya St., 15, 150000, Yaroslavl, Russia. tinkov.a.a@gmail.com.

10

Orenburg State Medical University, Orenburg, Russia. tinkov.a.a@gmail.com.

Abstract

Les enfants avec un diagnostic de TSA ont été caractérisés par des niveaux significativement plus élevés de cuivre (Cu) (+ 8%), de fer (Fe) (+ 5%) et de sélénium (Se) (+ 13%) dans les cheveux et seulement 8% de plus de sérum de Cu. Après la stratification pour le genre, les garçons avec un diagnostic de TSA se caractérisaient par une augmentation significative des niveaux de Cu (+ 25%), de Fe (+ 25%) et de Se (+ 9%), alors que chez les filles, seul le contenu de SE était élevé (+ 15%).
Les garçons et les filles avec un diagnostic de TSA ont été caractérisés par plus grand niveau sérique de manganèse (Mn) significativement plus élevé (+ 20%) et de Cu (+ 18%) par rapport aux valeurs des témoins.
Dans le groupe des enfants plus jeunes (2-5 ans), aucune différence significative de groupe dans les niveaux d'oligo-éléments des cheveux n'a été détectée, alors que les concentrations sériques de Cu étaient significativement plus élevées (+ 7%).  
À son tour, la concentration sérique de Se chez les enfants avec un diagnostic de TSA était inférieure de 11% à celle des enfants neurotypiques. Dans le groupe des enfants plus âgés avec un diagnostic de TSA (6 à 10 ans), les niveaux de cheveux Fe et Se étaient de 21% et 16% plus élevés, alors que dans le sérum, les niveaux de Cu ont augmenté (+ 12%) par rapport aux témoins. L'analyse de corrélation a également révélé une relation différente entre les niveaux des oligo-éléments du sérum et des cheveux par rapport au genre et à l'âge.  
Par conséquent, il est fortement recommandé d'évaluer plusieurs matrices bioindicatives pour l'évaluation critique de l'état des oligo-éléments chez les patients avec un diagnostic de TSA afin de développer une correction nutritionnelle personnalisée adéquate. 
The primary objective of the present study was to investigate the levels of essential trace elements in hair and serum in children with autism spectrum disorder (ASD) and investigate the age and gender effects. Children with ASD were characterized by significantly higher levels of copper (Cu) (+8%), iron (Fe) (+5%), and selenium (Se) (+13%) levels in hair and only 8% higher serum Cu levels. After stratification for gender, ASD boys were characterized by significantly increased hair Cu (+ 25%), Fe (+ 25%), and Se (+ 9%) levels, whereas in girls only Se content was elevated (+ 15%). Boys and girls suffering from ASD were characterized by significantly higher serum manganese (Mn) (+20%) and Cu (+18%) as compared to the control values, respectively. In the group of younger children (2-5 years), no significant group difference in hair trace element levels was detected, whereas serum Cu levels were significantly higher (+7%). In turn, the serum concentration of Se in ASD children was 11% lower than that in neurotypical children. In the group of older children with ASD (6-10 years), hair Fe and Se levels were 21% and 16% higher, whereas in serum only Cu levels were increased (+12%) as compared to the controls. Correlation analysis also revealed a different relationship between serum and hair trace element levels with respect to gender and age. Therefore, it is highly recommended to assess several bioindicative matrices for critical evaluation of trace element status in patients with ASD in order to develop adequate personalized nutritional correction.

PMID:28664504

DOI:10.1007/s11011-017-0056-7

Relation entre le sélénium, le plomb et le mercure dans les globules rouges des enfants autistes saoudiens

Aperçu: G.M.

Les données obtenues démontrent une élévation significative du Hg et du Pb ainsi qu'une diminution significative des taux de Se dans les globules rouges des patients avec TSA par rapport aux témoins sans TSA.

Metab Brain Dis. 2017 Mar 21. doi: 10.1007/s11011-017-9996-1.

Relationship between selenium, lead, and mercury in red blood cells of Saudi autistic children

El-Ansary A^1,2,3, Bjørklund G⁴, Tinkov AA^5,6,7, Skalny AV^6,7,8,9, Al Dera H^10,11.

Author information

1

Central Laboratory, Center for Female Scientific and Medical Colleges, King Saud University, Riyadh, Saudi Arabia.

2

Autism Research and Treatment Center, Riyadh, Saudi Arabia.

3

Medicinal Chemistry Department, National Research Centre, Dokki, Cairo, Egypt.

4

Council for Nutritional and Environmental Medicine, Toften 24, 8610, Mo i Rana, Norway. bjorklund@conem.org.

5

Orenburg State University, Orenburg, Russia.

6

Orenburg State Medical University, Orenburg, Russia.

7

Yaroslavl State University, Yaroslavl, Russia.

8

RUDN University, Moscow, Russia.

9

All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russia.

10

Basic Medical Science Department, College of Medicine, King Saud bin Abdul Aziz University for Health Sciences, Riyadh, Saudi Arabia.

11

King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can cause significant social, communication and behavioral challenges. Environmental contribution to ASD is due in large part to the sensitivity of the developing brain to external exposures such as lead (Pb), and mercury (Hg) as toxic heavy metals or due to a poor detoxification ability as the phenotype of this disorder. Selenium (Se) as an antioxidant element that counteracts the neurotoxicity of Hg, and Pb, presumably through the formation of nontoxic complexes. In the present study, Pb, Hg, and Se were measured in red blood cells (RBCs) of 35 children with ASD and 30 age- and gender-matched healthy control children using atomic absorption spectrometry. Receiver Operating Characteristics (ROC) analysis of the obtained data was performed to measure the predictive value of their absolute and relative concentrations. The obtained data demonstrates a significant elevation of Hg and Pb together with a significant decrease in the Se levels in RBCs of patients with ASD when compared to the healthy controls. The ratios of Se to both Pb and Hg were remarkably altered, being indicative of heavy metal neurotoxicity in patients with ASD. In conclusion, the present study indicates the importance of Se for prevention and/or therapy of heavy metal neurotoxicity.

PMID: 28326463

DOI: 10.1007/s11011-017-9996-1