Inventaire du comportement de l'autisme: un nouvel outil pour évaluer le noyau et les symptômes associés au trouble du spectre de l'autisme

Aperçu: G.M.

L'Inventaire du comportement autistique (ABI) est une nouvelle mesure pour évaluer les changements dans le noyau et les symptômes associés du trouble du spectre de l'autisme (TSA) chez les participants (âges: 3 ans-âge adulte) diagnostiqués avec TSA. Il s'agit d'un outil basé sur le Web avec cinq domaines (deux domaines principaux TSA: communication sociale, comportements restrictifs et répétitifs, trois domaines associés: santé mentale, autorégulation et comportement difficile). Cette étude décrit la conception, le développement et les propriétés psychométriques initiales de l'ABI.

Dans l'ensemble, ABI se révèle prometteur en tant qu'outil de mesure des changements dans les symptômes essentiels de l'autisme dans les études cliniques sur le TSA, avec une validation supplémentaire requise.

J Child Adolesc Psychopharmacol. 2017 May 12. doi: 10.1089/cap.2017.0018. ]

Autism Behavior Inventory: A Novel Tool for Assessing Core and Associated Symptoms of Autism Spectrum Disorder

Bangerter A¹, Ness S¹, Aman MG², Esbensen AJ³, Goodwin MS⁴, Dawson G⁵, Hendren R⁶, Leventhal B⁷, Khan A⁸, Opler M⁹, Harris A⁵, Pandina G¹.

Author information

1

1 Janssen Research & Development, LLC , Titusville, New Jersey.

2

2 The Nisonger Center University Center for Excellence in Developmental Disabilities (UCEDD), Ohio State University , Columbus, Ohio.

3

3 Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio.

4

4 312E Robinson Hall, Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University , Boston, Massachusetts.

5

5 Duke Center for Autism and Brain Development, Duke University , Durham, North Carolina.

6

6 Department of Psychiatry, University of California , San Francisco, California.

7

7 UCSF Benioff Children's Hospital , San Francisco, California.

8

8 Nathan Kline Institute , Orangeburg, New York.

9

9 ProPhase, LLC, NYU School of Medicine, Columbia University Medical Center , New York, New York.

Abstract

OBJECTIVE:

Autism Behavior Inventory (ABI) is a new measure for assessing changes in core and associated symptoms of autism spectrum disorder (ASD) in participants (ages: 3 years-adulthood) diagnosed with ASD. It is a web-based tool with five domains (two ASD core domains: social communication, restrictive and repetitive behaviors; three associated domains: mental health, self-regulation, and challenging behavior). This study describes design, development, and initial psychometric properties of the ABI.

METHODS:

ABI items were generated following review of existing measures and inputs from expert clinicians. Initial ABI scale contained 161 items that were reduced to fit a factor analytic model, retaining items of adequate reliability. Two versions of the scale, ABI-full (ABI-F; 93 items) and ABI-short version (ABI-S; 36 items), were developed and evaluated for psychometric properties, including validity comparisons with commonly used measures. Both scales were administered to parents and healthcare professionals (HCPs) involved with study participants.

RESULTS:

Test-retest reliability (intraclass correlation coefficient [ICC] = 0.79) for parent ratings on ABI was robust and compared favorably to existing scales. Test-retest correlations for HCP ratings were generally lower versus parent ratings. ABI core domains and comparison measures strongly correlated (r ≥ 0.70), demonstrating good concurrent validity.

CONCLUSIONS:

Overall, ABI demonstrates promise as a tool for measuring change in core symptoms of autism in ASD clinical studies, with further validation required.

PMID: 28498053

DOI: 10.1089/cap.2017.0018