Aperçu: G.M.
La
reconnaissance de l'émotion est perturbée dans de nombreux troubles de
santé mentale, ce qui peut refléter l'étiologie génétique partagée entre
ce trait et ces troubles. Des
études d'association à l'échelle du génome ont été réalisées pour
évaluer les associations avec la reconnaissance des émotions et des
émotions individuelles en général. Le
score exploratoire de risque polygénique a été effectué en utilisant
des données génomiques publiées pour la schizophrénie, le trouble
bipolaire, la dépression, le "trouble du spectre de l'autisme", l'anorexie
et les troubles anxieux.
Aucune
variable génétique individuelle n'a été identifiée à des niveaux
classiques de signification dans aucune analyse bien que plusieurs loci
aient été associés à un niveau suggérant une signification. Les analyses d'héritabilité de la puce à ADN n'ont pas identifié un composant héréditaire de variance pour tout phénotype.
Am J Med Genet B Neuropsychiatr Genet. 2017 Jun 13. doi: 10.1002/ajmg.b.32558.
Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders
Author information
- 1
- King's College London, Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK.
- 2
- National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London, UK.
- 3
- School of Psychology, University of Sussex, Brighton, UK.
- 4
- School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.
- 5
- MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
- 6
- UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, UK.
Abstract
Emotion
recognition is disrupted in many mental health disorders, which may
reflect shared genetic aetiology between this trait and these disorders.
We explored genetic influences on emotion recognition and the
relationship between these influences and mental health phenotypes.
Eight-year-old participants (n = 4,097) from the Avon Longitudinal Study
of Parents and Children (ALSPAC) completed the Diagnostic Analysis of
Non-Verbal Accuracy (DANVA) faces test. Genome-wide genotype data was
available from the Illumina HumanHap550 Quad microarray. Genome-wide
association studies were performed to assess associations with
recognition of individual emotions and emotion in general. Exploratory
polygenic risk scoring was performed using published genomic data for
schizophrenia, bipolar disorder, depression, autism spectrum disorder,
anorexia, and anxiety disorders. No individual genetic variants were
identified at conventional levels of significance in any analysis
although several loci were associated at a level suggestive of
significance. SNP-chip heritability analyses did not identify a
heritable component of variance for any phenotype. Polygenic scores were
not associated with any phenotype. The effect sizes of variants
influencing emotion recognition are likely to be small. Previous studies
of emotion identification have yielded non-zero estimates of
SNP-heritability. This discrepancy is likely due to differences in the
measurement and analysis of the phenotype.
© 2017 Wiley Periodicals, Inc.
- PMID:28608620
- DOI:10.1002/ajmg.b.32558
