Le rôle du métabolisme du cholestérol et diverses anomalies des stéroïdes dans les troubles du spectre autistique

Aperçu: G.M.

Sur la base des preuves de la littérature de recherche pertinente, l'étude présente une hypothèse selon laquelle il peut y avoir un lien entre le taux de cholestérol, la vitamine D et les hormones stéroïdiennes qui a par la suite influé sur le développement d'au moins certains des «autismes» 

Autism Res. 2017 Apr 12. doi: 10.1002/aur.1777.

The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper

Gillberg C¹, Fernell E¹, Kočovská E^1,2, Minnis H^1,3, Bourgeron T^4,5,6,7, Thompson L^1,3, Allely CS^1,8,9.

Author information

1

Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

2

Barts and London School of Medicine, Queen Mary University of London, Blizard Institute, 58 Turner Street, E1 2AB, London.

3

Institute of Health and Wellbeing, University of Glasgow, RHSC Yorkhill, Glasgow, Scotland, G3 8SJ, United Kingdom.

4

Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France.

5

CNRS UMR 3571: Genes, Synapses and Cognition, Institut Pasteur, Paris, France.

6

Université Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, Paris, France.

7

FondaMental Foundation, Créteil, France.

8

School of Health Sciences, University of Salford, Manchester, England.

9

Honorary Research Fellow in the College of Medical, Veterinary and Life Sciences affiliated to the Institute of Health and Wellbeing at the University of Glasgow.

Abstract

Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the "autisms" [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as "steroid metabolism" and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. Autism Res 2017. © 2017 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research.

© 2017 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research.

PMID: 28401679

DOI: 10.1002/aur.1777