Aperçu: G.M.
Les
troubles du spectre autistique et la schizophrénie sont associés à une
activité métabolique accrue dans l'ensemble de la substance blanche. Contrairement à la substance grise, le vecteur des anomalies
métaboliques de la substance blanche semble être similaire dans les TSA
et la schizophrénie, peut refléter une connectivité fonctionnelle
inefficace avec un hypermétabolisme compensatoire, et peut être une
caractéristique commune des troubles neurodéveloppementaux.
Brain Imaging Behav. 2017 Nov 22. doi: 10.1007/s11682-017-9785-9.
Increased white matter metabolic rates in autism spectrum disorder and schizophrenia
Mitelman SA1,2, Buchsbaum MS3, Young DS4, Haznedar MM5,6, Hollander E7, Shihabuddin L5, Hazlett EA5,8, Bralet MC9,10,11.
Author information
- 1
- Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. serge.mitelman@mssm.edu
- 2
- Department of Psychiatry, Division of Child and Adolescent Psychiatry, Elmhurst Hospital Center, 79-01 Broadway, Elmhurst, NY, 11373, USA. serge.mitelman@mssm.edu.
- 3
- Departments of Psychiatry and Radiology, San Diego School of Medicine, NeuroPET Center, University of California, 11388 Sorrento Valley Road, Suite #100, San Diego, CA, 92121, USA.
- 4
- Department of Statistics, University of Kentucky, 725 Rose Street, 323 Multidisciplinary Science Building, Lexington, KY, 40536, USA.
- 5
- Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
- 6
- Outpatient Psychiatry Care Center, James J. Peters VA Medical Center, Bronx, NY, 10468, USA.
- 7
- Autism and Obsessive-Compulsive Spectrum Program, Anxiety and Depression Program, Department of Psychiatry and Behavioral Science, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, 10467, USA.
- 8
- Research and Development and VISN 2 Mental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center, Bronx, NY, 10468, USA.
- 9
- Crisalid Unit (FJ5), CHI Clermont de l'Oise, 2 rue des Finets, 60607, Clermont, France.
- 10
- Inserm Unit U669, Maison de Solenn, Universities Paris 5-11, 75014, Paris, France.
- 11
- GDR 3557 Recherche Psychiatrie, Paris, France.
Abstract
Both autism spectrum disorder
(ASD) and schizophrenia are often characterized as disorders of white
matter integrity. Multimodal investigations have reported elevated
metabolic rates, cerebral perfusion and basal activity in various white
matter regions in schizophrenia, but none of these functions has
previously been studied in ASD. We used 18fluorodeoxyglucose
positron emission tomography to compare white matter metabolic rates in
subjects with ASD (n = 25) to those with schizophrenia (n = 41) and
healthy controls (n = 55) across a wide range of stereotaxically placed
regions-of-interest. Both subjects with ASD and schizophrenia showed
increased metabolic rates across the white matter regions assessed,
including internal capsule, corpus callosum, and white matter in the
frontal and temporal lobes. These increases were more pronounced, more
widespread and more asymmetrical in subjects with ASD than in those with
schizophrenia. The highest metabolic increases in both disorders were
seen in the prefrontal white matter and anterior limb of the internal
capsule. Compared to normal controls, differences in gray matter
metabolism were less prominent and differences in adjacent white matter
metabolism were more prominent in subjects with ASD than in those with
schizophrenia. Autism spectrum disorder
and schizophrenia are associated with heightened metabolic activity
throughout the white matter. Unlike in the gray matter, the vector of
white matter metabolic abnormalities appears to be similar in ASD and
schizophrenia, may reflect inefficient functional connectivity with
compensatory hypermetabolism, and may be a common feature of
neurodevelopmental disorders.
- PMID:29168086
- DOI:10.1007/s11682-017-9785-9
