Aperçu: G.M.
Les déficits de contrôle de la force ont été documentés à plusieurs reprises dans le trouble du spectre de l'autisme (TSA). Ils
sont associés à une plus grande détérioration des habiletés sociales et de la
vie quotidienne chez les personnes, ce qui suggère que développer une compréhension plus mécanique des processus centraux et périphériques
qui les causent peut aider à guider le développement de traitements qui
améliorent les résultats multiples dans le TSA.
Les personnes avec un diagnostic de TSA présentaient une plus grande variabilité de
force que les témoins lorsqu'ils essayaient de maintenir une force
constante. Ces résultats suggèrent que des altérations des mécanismes centraux
qui contrôlent le déclenchement d'ensembles de motoneurones peuvent
sous-tendre les symptômes communs et souvent invalidants des TSA.
Int J Mol Sci. 2017 Mar 25;18(4). pii: E698. doi: 10.3390/ijms18040698.
Increased Force Variability Is Associated with Altered Modulation of the Motorneuron Pool Activity in Autism Spectrum Disorder (ASD)
Wang Z1,2,3, Kwon M4,5,6, Mohanty S7, Schmitt LM8,9,10, White SP11, Christou EA12, Mosconi MW13,14,15.
Author information
- 1
- Schiefelbusch Institute for Life Span Studies, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. zhengwang@ku.edu
- 2
- Clinical Child Psychology Program, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. zhengwang@ku.edu.
- 3
- Kansas Center for Autism Research and Training (K-CART), University of Kansas Medical School, Overland Park, KS 66213, USA. zhengwang@ku.edu.
- 4
- Schiefelbusch Institute for Life Span Studies, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. minhyuk.kwon@marquette.edu.
- 5
- Clinical Child Psychology Program, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. minhyuk.kwon@marquette.edu.
- 6
- Kansas Center for Autism Research and Training (K-CART), University of Kansas Medical School, Overland Park, KS 66213, USA. minhyuk.kwon@marquette.edu.
- 7
- Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. smohanty3@humana.com.
- 8
- Schiefelbusch Institute for Life Span Studies, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. lmschmitt@ku.edu.
- 9
- Clinical Child Psychology Program, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. lmschmitt@ku.edu.
- 10
- Kansas Center for Autism Research and Training (K-CART), University of Kansas Medical School, Overland Park, KS 66213, USA. lmschmitt@ku.edu.
- 11
- Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Stormi.White@UTsouthwestern.edu.
- 12
- Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. eachristou@hhp.ufl.edu.
- 13
- Schiefelbusch Institute for Life Span Studies, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. mosconi@ku.edu.
- 14
- Clinical Child Psychology Program, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. mosconi@ku.edu.
- 15
- Kansas Center for Autism Research and Training (K-CART), University of Kansas Medical School, Overland Park, KS 66213, USA. mosconi@ku.edu.
Abstract
Force control deficits have been repeatedly documented in autism spectrum disorder
(ASD). They are associated with worse social and daily living skill
impairments in patients suggesting that developing a more mechanistic
understanding of the central and peripheral processes that cause them
may help guide the development of treatments that improve multiple
outcomes in ASD. The neuromuscular mechanisms underlying force control
deficits are not yet understood. Seventeen individuals with ASD and 14
matched healthy controls completed an isometric index finger abduction
test at 60% of their maximum voluntary contraction (MVC) during
recording of the first dorsal interosseous (FDI) muscle to determine the
neuromuscular processes associated with sustained force variability.
Central modulation of the motorneuron pool activation of the FDI muscle
was evaluated at delta (0-4 Hz), alpha (4-10 Hz), beta (10-35 Hz) and
gamma (35-60 Hz) frequency bands. ASD patients showed greater force
variability than controls when attempting to maintain a constant force.
Relative to controls, patients also showed increased central modulation
of the motorneuron pool at beta and gamma bands. For controls, reduced
force variability was associated with reduced delta frequency modulation
of the motorneuron pool activity of the FDI muscle and increased
modulation at beta and gamma bands. In contrast, delta, beta, and gamma
frequency oscillations were not associated with force variability in
ASD. These findings suggest that alterations of central mechanisms that
control motorneuron pool firing may underlie the common and often
impairing symptoms of ASD.
- PMID: 28346344
- DOI: 10.3390/ijms18040698
