Les oscillationsTheta pendant le sommeil actif synchronise le réseau sensorimotor Rubro-Hippocampal en développement

Aperçu: G.M.

Les oscillations neuronales constituent un mécanisme fondamental par lequel les structures nerveuses éloignées établissent et expriment une connectivité fonctionnelle. La connectivité fonctionnelle à longue distance entre l'hippocampe et d'autres structures du cerveau antérieur est activée par les oscillations theta.

L'étude montre pour la première fois que le noyau rouge de rat de nourrisson (RN) - une structure du tronc sensoriel montrent des oscillations theta (4-7 Hz) limitées principalement aux périodes de sommeil actif (REM).  

Curr Biol. 2017 May 3. pii: S0960-9822(17)30407-4. doi: 10.1016/j.cub.2017.03.077.

Theta Oscillations during Active Sleep Synchronize the Developing Rubro-Hippocampal Sensorimotor Network

Del Rio-Bermudez C¹, Kim J², Sokoloff G¹, Blumberg MS³.

Author information

1

Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; DeLTA Center, University of Iowa, Iowa City, IA 52242, USA.

2

Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA.

3

Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, USA; Department of Biology, University of Iowa, Iowa City, IA 52242, USA; DeLTA Center, University of Iowa, Iowa City, IA 52242, USA. Electronic address: mark-blumberg@uiowa.edu

Abstract

Neuronal oscillations comprise a fundamental mechanism by which distant neural structures establish and express functional connectivity. Long-range functional connectivity between the hippocampus and other forebrain structures is enabled by theta oscillations. Here, we show for the first time that the infant rat red nucleus (RN)-a brainstem sensorimotor structure-exhibits theta (4-7 Hz) oscillations restricted primarily to periods of active (REM) sleep. At postnatal day 8 (P8), theta is expressed as brief bursts immediately following myoclonic twitches; by P12, theta oscillations are expressed continuously across bouts of active sleep. Simultaneous recordings from the hippocampus and RN at P12 show that theta oscillations in both structures are coherent, co-modulated, and mutually interactive during active sleep. Critically, at P12, inactivation of the medial septum eliminates theta in both structures. The developmental emergence of theta-dependent functional coupling between the hippocampus and RN parallels that between the hippocampus and prefrontal cortex. Accordingly, disruptions in the early expression of theta could underlie the cognitive and sensorimotor deficits associated with neurodevelopmental disorders such as autism and schizophrenia.

Copyright © 2017 Elsevier Ltd. All rights reserved.

PMID:28479324

DOI:10.1016/j.cub.2017.03.077