Aperçu: G.M.
Les
caractéristiques communes entre les "troubles du spectre de l'autisme"
(TSA) et le cancer ont été discernées en utilisant des méthodologies à
partir d'un certain nombre de disciplines, incluant la génétique, la
bioinformatique et les études épidémiologiques. Pour
comprendre de tels chevauchements apparents entre ces deux conditions
et les mécanismes qui sous-tendent ces liens, il est important
d'examiner leur contexte de systèmes à plusieurs niveaux. Les chercheurs explorent les
liens entre TSA et cancer à travers des niveaux allant des gènes aux
voies et aux systèmes, ainsi que du point de vue du mécanisme et des
études cliniques et épidémiologiques.
L'examen
des résultats existants a permis de prouver que les TSA et le cancer se
chevauchent largement dans les voies de transduction des signaux impliquées dans les processus métaboliques.
Med Hypotheses. 2017 Jun;103:118-123. doi: 10.1016/j.mehy.2017.05.004. Epub 2017 May 5.
Connecting the dots: Verlans between autism and cancer suggest possible common mechanisms regarding signaling pathways related to metabolic alterations
Wen Y1, Herbert MR2.
Author information
- 1
- TRANSCEND Research, Neurology Department, Massachusetts General Hospital, Charlestown, MA, United States; Harvard Medical School, Harvard University, Boston, MA, United States; Higher Synthesis Foundation, Cambridge, MA, United States. Electronic address: ywen3@mgh.harvard.edu.
- 2
- TRANSCEND Research, Neurology Department, Massachusetts General Hospital, Charlestown, MA, United States; Harvard Medical School, Harvard University, Boston, MA, United States; Higher Synthesis Foundation, Cambridge, MA, United States.
Abstract
Common
features between autism spectrum disorders (ASDs) and cancer have been
discerned using methodologies from a number of disciplines, including
genetics, bioinformatics and epidemiological studies. To understand such
apparent overlaps between these two conditions and the mechanisms that
may underlie these linkages, it is important to look at their
multi-level systems context. Here we discuss ASDs and cancer linkages
across levels ranging from genes to pathways and systems, as well as
from the vantage points of mechanism and of clinical and epidemiological
studies. Review of existing findings yielded evidence that ASDs and
cancer overlap extensively in signal transduction pathways that are
involved in metabolic processes. We hypothesize that further studies
focusing on illuminating the relationships between ASDs and cancer,
specifically with regard to signaling pathways that regulate metabolic
activities, could help shed new insight on these conditions and develop
treatment strategies that, by targeting underlying mechanisms, may be
more efficient and effective for both conditions.
Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
- PMID:28571796
- DOI:10.1016/j.mehy.2017.05.004
