Relier les points: les chevauchements entre l'autisme et le cancer suggèrent des mécanismes communs possibles concernant les voies de signalisation liées aux altérations métaboliques

Aperçu: G.M.

Les caractéristiques communes entre les "troubles du spectre de l'autisme" (TSA) et le cancer ont été discernées en utilisant des méthodologies à partir d'un certain nombre de disciplines, incluant la génétique, la bioinformatique et les études épidémiologiques. Pour comprendre de tels chevauchements apparents entre ces deux conditions et les mécanismes qui sous-tendent ces liens, il est important d'examiner leur contexte de systèmes à plusieurs niveaux. Les chercheurs explorent les liens entre TSA et cancer à travers des niveaux allant des gènes aux voies et aux systèmes, ainsi que du point de vue du mécanisme et des études cliniques et épidémiologiques.

L'examen des résultats existants a permis de prouver que les TSA et le cancer se chevauchent largement dans les voies de transduction des signaux impliquées dans les processus métaboliques.

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Med Hypotheses. 2017 Jun;103:118-123. doi: 10.1016/j.mehy.2017.05.004. Epub 2017 May 5.

Connecting the dots: Verlans between autism and cancer suggest possible common mechanisms regarding signaling pathways related to metabolic alterations

Wen Y¹, Herbert MR².

Author information

1

TRANSCEND Research, Neurology Department, Massachusetts General Hospital, Charlestown, MA, United States; Harvard Medical School, Harvard University, Boston, MA, United States; Higher Synthesis Foundation, Cambridge, MA, United States. Electronic address: ywen3@mgh.harvard.edu.

2

TRANSCEND Research, Neurology Department, Massachusetts General Hospital, Charlestown, MA, United States; Harvard Medical School, Harvard University, Boston, MA, United States; Higher Synthesis Foundation, Cambridge, MA, United States.

Abstract

Common features between autism spectrum disorders (ASDs) and cancer have been discerned using methodologies from a number of disciplines, including genetics, bioinformatics and epidemiological studies. To understand such apparent overlaps between these two conditions and the mechanisms that may underlie these linkages, it is important to look at their multi-level systems context. Here we discuss ASDs and cancer linkages across levels ranging from genes to pathways and systems, as well as from the vantage points of mechanism and of clinical and epidemiological studies. Review of existing findings yielded evidence that ASDs and cancer overlap extensively in signal transduction pathways that are involved in metabolic processes. We hypothesize that further studies focusing on illuminating the relationships between ASDs and cancer, specifically with regard to signaling pathways that regulate metabolic activities, could help shed new insight on these conditions and develop treatment strategies that, by targeting underlying mechanisms, may be more efficient and effective for both conditions.

Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

PMID:28571796

DOI:10.1016/j.mehy.2017.05.004