Régime sans gluten et sans caséine et "troubles du spectre de l'autisme" chez les enfants: une revue systématique

Aperçu: G.M.

Des traitements efficaces pour les symptômes de base des "troubles du spectre de l'autisme"(TSA) font défaut. L'étude a systématiquement mis à jour des preuves sur l'efficacité d'un régime sans gluten et sans caséine (SGSC) en tant que traitement pour les TSA chez les enfants.

Six essais contrôlés randomisés (ECR) ont été obtenues à partir d'articles examinés (214 participants).À quelques exceptions près, il n'y avait pas de différences statistiquement significatives dans les symptômes de base du trouble du spectre de l'autisme entre les groupes, mesurés par des échelles normalisées.

Aucun événement indésirable associé à un régime de FBCF n'a été signalé. 

Eur J Nutr. 2017 Jun 13. doi: 10.1007/s00394-017-1483-2.

Gluten- and casein-free diet and autism spectrum disorders in children: a systematic review

Piwowarczyk A¹, Horvath A², Łukasik J³, Pisula E⁴, Szajewska H³.

Author information

1

Department of Paediatrics with Clinical Decisions Unit, The Medical University of Warsaw, Żwirki i Wigury 63a, 02-091, Warsaw, Poland.

2

Department of Paediatrics, The Medical University of Warsaw, Żwirki i Wigury 63a, 02-091, Warsaw, Poland. andrea.hania@gmail.com.

3

Department of Paediatrics, The Medical University of Warsaw, Żwirki i Wigury 63a, 02-091, Warsaw, Poland.

4

Department of Rehabilitation Psychology, University of Warsaw, Stawki 5/7, 00-183, Warsaw, Poland.

Abstract

PURPOSE:

Effective treatments for core symptoms of autism spectrum disorders (ASD) are lacking. We systematically updated evidence on the effectiveness of a gluten-free and casein-free (GFCF) diet as a treatment for ASD in children.

METHODS:

The Cochrane Library, MEDLINE, and EMBASE databases were searched up until August 2016, for randomized controlled trials (RCTs); additional references were obtained from reviewed articles.

RESULTS:

Six RCTs (214 participants) were included. With few exceptions, there were no statistically significant differences in autism spectrum disorder core symptoms between groups, as measured by standardized scales. One trial found that compared with the control group, in the GFCF diet group there were significant improvements in the scores for the 'communication' subdomain of the Autism Diagnostic Observation Schedule and for the 'social interaction' subdomain of the Gilliam Autism Rating Scale. Another trial found significant differences between groups in the post-intervention scores for the 'autistic traits', 'communication', and 'social contact' subdomains of a standardized Danish scheme. The remaining differences, if present, referred to parent-based assessment tools or other developmental/ASD-related features. No adverse events associated with a GFCF diet were reported.

CONCLUSIONS:

Overall, there is little evidence that a GFCF diet is beneficial for the symptoms of ASD in children.

PMID:28612113

DOI:10.1007/s00394-017-1483-2