12 juin 2017

Protocole d'étude du ASD-Net, le consortium de recherche allemand pour l'étude du trouble du spectre autistique tout au long de la vie: d'une meilleure compréhension étiologique, par un diagnostic valide, à des soins de santé plus efficaces

Aperçu: G.M.
Le "trouble du spectre de l'autisme" (TSA) est un trouble neurologique sévère et durable qui a un début précoce qui constitue un lourd fardeau pour les personnes touchées et leurs familles. En raison de la nécessité de services de santé, d'éducation et de formation professionnelle hautement spécialisés, la TSA est un trouble à forte intensité de coût et la tension sur les systèmes de soins de santé augmente avec l'âge de l'individu touché.
Le TSA-Net étudiera la plus grande cohorte de patients atteints de TSA en Allemagne pendant la durée de vie. En combinant l'expertise méthodologique de tous les niveaux de recherche clinique, l'ASD-Net suivra une approche translationnelle nécessaire pour identifier les voies neurobiologiques de différents phénotypes et leur identification et traitement appropriés.
 


BMC Psychiatry. 2017 Jun 2;17(1):206. doi: 10.1186/s12888-017-1362-7.

Study protocol of the ASD-Net, the German research consortium for the study of Autism Spectrum Disorder across the lifespan: from a better etiological understanding, through valid diagnosis, to more effective health care

Author information

1
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Clinic, Philipps-University Marburg, Marburg, Germany. kampbeck@med.uni-marburg.de
2
Department of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
3
Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
4
Department of Child and Adolescent Psychiatry/Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
5
Faculty of Medicine, Philipps University Marburg, Marburg, Germany.
6
Department of Child & Adolescent Psychiatry, Medical Faculty of the Technical University Dresden, Dresden, Germany.
7
Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
8
Department of Health Services Research, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
9
Department of Social Neuroscience, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
10
Department of Clinical Psychology Central Institute of Mental Health, Mannheim, Germany.
11
Department for Psychiatry and Psychotherapy, University Schleswig-Holstein Campus Lübeck, Lübeck, Germany.
12
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany.
13
Department of Psychiatry, Campus Benjamin Franklin, Charité - Medical Faculty Berlin, Berlin, Germany.
14
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Clinic, Philipps-University Marburg, Marburg, Germany.

Abstract

BACKGROUND:

Autism Spectrum Disorder (ASD) is a severe, lifelong neurodevelopmental disorder with early onset that places a heavy burden on affected individuals and their families. Due to the need for highly specialized health, educational and vocational services, ASD is a cost-intensive disorder, and strain on health care systems increases with increasing age of the affected individual.

METHODS:

The ASD-Net will study Germany's largest cohort of patients with ASD over the lifespan. By combining methodological expertise from all levels of clinical research, the ASD-Net will follow a translational approach necessary to identify neurobiological pathways of different phenotypes and their appropriate identification and treatment. The work of the ASD-Net will be organized into three clusters concentrating on diagnostics, therapy and health economics. In the diagnostic cluster, data from a large, well-characterized sample (N = 2568) will be analyzed to improve the efficiency of diagnostic procedures. Pattern classification methods (machine learning) will be used to identify algorithms for screening purposes. In a second step, the developed algorithm will be tested in an independent sample. In the therapy cluster, we will unravel how an ASD-specific social skills training with concomitant oxytocin administration can modulate behavior through neurobiological pathways. For the first time, we will characterize long-term effects of a social skills training combined with oxytocin treatment on behavioral and neurobiological phenotypes. Also acute effects of oxytocin will be investigated to delineate general and specific effects of additional oxytocin treatment in order to develop biologically plausible models for symptoms and successful therapeutic interventions in ASD. Finally, in the health economics cluster, we will assess service utilization and ASD-related costs in order to identify potential needs and cost savings specifically tailored to Germany. The ASD-Net has been established as part of the German Research Network for Mental Disorders, funded by the BMBF (German Federal Ministry of Education and Research).

DISCUSSION:

The highly integrated structure of the ASD-Net guarantees sustained collaboration of clinicians and researchers to alleviate individual distress, harm, and social disability of patients with ASD and reduce costs to the German health care system.

TRIAL REGISTRATION:

Both clinical trials of the ASD-Net are registered in the German Clinical Trials Register: DRKS00008952 (registered on August 4, 2015) and DRKS00010053 (registered on April 8, 2016).

KEYWORDS:

ASD-net; Autism spectrum disorder; Diagnosis; Genetic; German research network for mental disorders; Health economics; Oxytocin; Screening; Social competence training; Therapy
PMID:28577550
PMCID:PMC5455122
DOI:10.1186/s12888-017-1362-7

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