Étude de l'association génomique de la reconnaissance de l'émotion du visage chez les enfants et association avec le risque polygénique pour les troubles de santé mentale

Aperçu: G.M.

La reconnaissance de l'émotion est perturbée dans de nombreux troubles de santé mentale, ce qui peut refléter l'étiologie génétique partagée entre ce trait et ces troubles.  Des études d'association à l'échelle du génome ont été réalisées pour évaluer les associations avec la reconnaissance des émotions et des émotions individuelles en général. Le score exploratoire de risque polygénique a été effectué en utilisant des données génomiques publiées pour la schizophrénie, le trouble bipolaire, la dépression, le "trouble du spectre de l'autisme", l'anorexie et les troubles anxieux.

Aucune variable génétique individuelle n'a été identifiée à des niveaux classiques de signification dans aucune analyse bien que plusieurs loci aient été associés à un niveau suggérant une signification. Les analyses d'héritabilité de la puce à ADN n'ont pas identifié un composant héréditaire de variance pour tout phénotype.

Am J Med Genet B Neuropsychiatr Genet. 2017 Jun 13. doi: 10.1002/ajmg.b.32558.

Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders

Coleman JRI^1,2, Lester KJ³, Keers R^1,4, Munafò MR^5,6, Breen G^1,2, Eley TC^1,2.

Author information

1

King's College London, Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK.

2

National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, London, UK.

3

School of Psychology, University of Sussex, Brighton, UK.

4

School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.

5

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

6

UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, UK.

Abstract

Emotion recognition is disrupted in many mental health disorders, which may reflect shared genetic aetiology between this trait and these disorders. We explored genetic influences on emotion recognition and the relationship between these influences and mental health phenotypes. Eight-year-old participants (n = 4,097) from the Avon Longitudinal Study of Parents and Children (ALSPAC) completed the Diagnostic Analysis of Non-Verbal Accuracy (DANVA) faces test. Genome-wide genotype data was available from the Illumina HumanHap550 Quad microarray. Genome-wide association studies were performed to assess associations with recognition of individual emotions and emotion in general. Exploratory polygenic risk scoring was performed using published genomic data for schizophrenia, bipolar disorder, depression, autism spectrum disorder, anorexia, and anxiety disorders. No individual genetic variants were identified at conventional levels of significance in any analysis although several loci were associated at a level suggestive of significance. SNP-chip heritability analyses did not identify a heritable component of variance for any phenotype. Polygenic scores were not associated with any phenotype. The effect sizes of variants influencing emotion recognition are likely to be small. Previous studies of emotion identification have yielded non-zero estimates of SNP-heritability. This discrepancy is likely due to differences in the measurement and analysis of the phenotype.

© 2017 Wiley Periodicals, Inc.

PMID:28608620

DOI:10.1002/ajmg.b.32558