Aperçu: G.M.
Certaines études suggèrent que l'infection prénatale augmente le risque de "troubles du spectre de l'autisme" (TSA). Cette
étude a été entreprise dans une cohorte prospective en Norvège pour
examiner si nous pouvions trouver des preuves pour soutenir une
association de l'apparition prénatale de la fièvre, une manifestation
commune d'infection, avec un risque de TSA. Des questionnaires prospectifs ont fourni des données sur l'exposition maternelle.
Le
risque a augmenté nettement avec l'exposition à trois épisodes de
fièvre ou plus après 12 semaines de gestation.
Le risque de TSA semble augmenter avec la fièvre maternelle, en particulier au deuxième trimestre.
Le risque augmente proportionnellement de degré avec une exposition à de multiples fièvres après une grossesse de 12 semaines.
Ces résultats confortent le rôle de l'infection maternelle gestationnelle
et des réponses immunitaires innées à une infection dans la pathogenèse
d'au moins certains cas de TSA.
Mol Psychiatry. 2017 Jun 13. doi: 10.1038/mp.2017.119.
Prenatal fever and autism risk
Hornig M1,2, Bresnahan MA2,3, Che X1, Schultz AF1, Ukaigwe JE1, Eddy ML1, Hirtz D4, Gunnes N5, Lie KK5, Magnus P5, Mjaaland S5, Reichborn-Kjennerud T5,6, Schjølberg S5, Øyen AS5,7, Levin B8, Susser ES2,3, Stoltenberg C5,9, Lipkin WI1,2,10.
Author information
- 1
- Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
- 2
- Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
- 3
- New York State Psychiatric Institute, New York, NY, USA.
- 4
- National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD, USA.
- 5
- Norwegian Institute of Public Health, Oslo, Norway.
- 6
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
- 7
- Lovisenberg Diakonale Sykehus, Nic Waals Institutt, Oslo, Norway.
- 8
- Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
- 9
- Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
- 10
- Departments of Pathology and Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Abstract
Some
studies suggest that prenatal infection increases risk of autism
spectrum disorders (ASDs). This study was undertaken in a prospective
cohort in Norway to examine whether we could find evidence to support an
association of the prenatal occurrence of fever, a common manifestation
of infection, with ASD risk. Prospective questionnaires provided
maternal exposure data; case status was established from clinical
assessments and registry linkages. In a large, prospectively ascertained
cohort of pregnant mothers and their offspring, we examined infants
born ⩾32 weeks for associations between fever exposure in each trimester
and ASD risk using logistic regression. Maternal exposure to
second-trimester fever was associated with increased ASD risk, adjusting
for presence of fever in other trimesters and confounders (adjusted
odds ratio (aOR), 1.40; 95% confidence interval, 1.09-1.79), with a
similar, but nonsignificant, point estimate in the first trimester. Risk
increased markedly with exposure to three or more fever episodes after
12 weeks' gestation (aOR, 3.12; 1.28-7.63). ASD risk appears to increase
with maternal fever, particularly in the second trimester. Risk
magnified dose dependently with exposure to multiple fevers after 12
weeks' gestation. Our findings support a role for gestational maternal
infection and innate immune responses to infection in the pathogenesis
of at least some cases of ASD.Molecular Psychiatry advance online
publication, 13 June 2017; doi:10.1038/mp.2017.119.
- PMID:28607458
- DOI:10.1038/mp.2017.119
Aucun commentaire:
Enregistrer un commentaire