Aperçu: G.M.
Les comportements restreints et répétitifs (CRR) sont fréquents chez les personnes atteintes du syndrome de microdélétion 22q11.2 (22q11.2DS), mais les mécanismes sous-jacents de ces comportements restent mal caractérisés.
Dans la présente enquête pilote, nous voulions approfondir notre compréhension des RRB dans la 22q11.2DS en explorant leur relation avec le contrôle cognitif et l’anxiété, ainsi qu’avec le sexe, l’âge chronologique et le QI complet. Les parents de 38 enfants avec 22q11.2DS (17 filles; Mage = 11,15 ans, SD = 2,46) ont rempli le questionnaire sur la communication sociale en tant que mesure des problèmes de CRR et de problèmes sociaux et de communication (SC) et du système d'évaluation comportementale des enfants-2 en tant que mesure de l'anxiété et du contrôle cognitif.
Des scores CRR plus élevés étaient associés de manière significative à des niveaux d'anxiété plus élevés (r = 0,44, P = 0,006), à davantage de déficiences du contrôle cognitif (r = 0,56, P <0,001) et à des scores SC plus élevés (r = 0,43, P = 0,011). Dans la première étape du modèle de régression hiérarchique, l’anxiété représentait 24,5% de la variance (F = 10,05, P = 0,003); le contrôle cognitif a représenté 18,1% supplémentaires de la variance (Fchange = 11,15, P <0,001) à la deuxième étape; Le score SC ne représentait que 0,8% de la variance supplémentaire à la troisième étape (Fchange = 0,40, P = 0,53).
Le modèle final expliquait 43,4% de la variance (F = 7,42, P = 0,001), le contrôle cognitif étant un prédicteur indépendant unique du score CRR (t = 2,52, P = 0,01).
La présente étude constitue la première exploration du lien contrôle cognitif-anxiété-CRR chez les personnes atteintes de 22q11.2DS et indique que le contrôle cognitif est une cible potentiellement viable pour les traitements visant à réduire le CRR .
Autism Res. 2019 Aug 21. doi: 10.1002/aur.2194.
Interrelationship Between Cognitive Control, Anxiety, and Restricted and Repetitive Behaviors in Children with 22q11.2 Deletion Syndrome
Uljarević M1,2, McCabe KL3,4, Angkustsiri K4,5, Simon TJ3,4, Hardan AY1.
Author information
- 1
- Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
- 2
- Melbourne School of Psychological Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
- 3
- Department of Psychiatry and Behavioral Sciences, University of California, Davis, California.
- 4
- MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, California.
- 5
- Department of Pediatrics, University of California, Davis, Sacramento, California.
Abstract
Restricted
and repetitive behaviors (RRB) are common in individuals with 22q11.2
microdeletion syndrome (22q11.2DS), yet the underlying mechanisms of
these behaviors remain poorly characterized. In the present pilot
investigation, we aimed to further our understanding of RRB in 22q11.2DS
by exploring their relationship with cognitive control and anxiety as
well as with sex, chronological age, and full-scale IQ. Parents of 38
children with 22q11.2DS (17 females; Mage = 11.15 years, SD =
2.46) completed the Social Communication Questionnaire as a measure of
RRB and social and communication (SC) problems and the Behavioral
Assessment System for Children-2 as a measure of anxiety and cognitive
control. Higher RRB scores were significantly associated with higher
anxiety levels (r = 0.44, P = 0.006), more impairments in cognitive
control (r = 0.56, P < 0.001), and higher SC scores (r = 0.43, P =
0.011). In the first step of the hierarchical regression model, anxiety
accounted for 24.5% of variance (F = 10.05, P = 0.003); cognitive
control accounted for an additional 18.1% of variance (Fchange = 11.15,
P < 0.001) in the second step; SC score accounted for only 0.8% of
additional variance in the third step (Fchange = 0.40, P = 0.53). The
final model explained 43.4% of variance (F = 7.42, P = 0.001), with
cognitive control as a unique independent predictor of RRB score (t =
2.52, P = 0.01). The current study provides the first exploration of the
cognitive control-anxiety-RRB link in individuals with 22q11.2DS and
points to cognitive control as a potentially viable target for
treatments aimed at reducing RRB. Autism Res 2019. © 2019 International
Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People
with 22q11.2 deletion syndrome show high levels of repetitive
behaviors, however, the previous research has not explored why people
with this syndrome exhibit high rates of repetitive behaviors.
Understanding the reasons for the high levels of repetitive behaviors is
important given that these behaviors can be highly impairing. Our study
found that repetitive behaviors were associated with impaired ability
to self-regulate and high levels of anxiety. These findings need to be
further replicated; however, they are important as they suggest
potentially promising ways of reducing these behaviors.
© 2019 International Society for Autism Research, Wiley Periodicals, Inc.
- PMID:31433576
- DOI:10.1002/aur.2194
