Dysrégulation de la croissance squelettique chez les nourrissons et les tout-nourissons garçons australiens avec un diagnostic de "trouble du spectre de l'autisme"

Aperçu: G.M.

Des découvertes récentes suggèrent que les bébés avec un diagnostic de "trouble du spectre de l'autisme (dTSA) sont plus petits à la naissance que les nourrissons qui se développent de façon typique (TD), mais qu'ils deviennent plus gros que leurs pairs au cours de la première année. On sait peu de choses sur leur taux de croissance, en particulier pour la taille et le poids.  

La présente étude visait à: 

1. confirmer et étendre les résultats antérieurs de la surcroissance précoce généralisée des TSA; et 
2. déterminer s'il y avait des différences dans le taux de croissance entre les nourrissons et les tout-petits avec un dTSA comparativement à leurs pairs TD. 

Les résultats de létude ont confirmé que les nourrissons avec un dTSA sont de taille plus petite à la naissance pour le tour de tête (TT) , la taille et le poids, mais croissent plus rapidement en TT et en taille que leurs pairs de la naissance à 3 ans.

Autism Res. 2018 Apr 6. doi: 10.1002/aur.1952.

Skeletal Growth Dysregulation in Australian Male Infants and Toddlers With Autism Spectrum Disorder

Green CC^1,2, Dissanayake C¹, Loesch DZ³, Bui M⁴, Barbaro J¹.

Author information

1

Olga Tennison Autism Research Centre, School of Psychology and Public Health, La Trobe University, Bundoora, Victoria, Australia.

2

Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.

3

School of Psychology and Public Health, La Trobe University, Bundoora, Victoria, Australia.

4

Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.

Abstract

Recent findings suggest that children with Autism Spectrum Disorder (ASD) are larger in size for head circumference (HC), height, and weight compared to typically developing (TD) children; however, little is known about their rate of growth, especially in height and weight. The current study aimed to: (a) confirm and extend upon previous findings of early generalized overgrowth in ASD; and (b) determine if there were any differences in the rate of growth between infants and toddlers with ASD compared to their TD peers. Measurements of HC, height, and weight were available for 135 boys with ASD and 74 TD boys, from birth through 3 years of age. Size and growth rate in HC, height, and weight were analyzed using a linear mixed-effects model. Infants with ASD were significantly smaller in size at birth for HC, body length, and weight compared to TD infants (all P < 0.05); however, they grew at a significantly faster rate in HC and height in comparison to the TD children (P < 0.001); there was no significant difference between the groups in growth rate for weight (P > 0.05). The results confirmed that male infants and toddlers with ASD exhibit skeletal growth dysregulation early in life. Autism Res 2018. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.

LAY SUMMARY:

Recent findings suggest that infants with Autism Spectrum Disorder (ASD) are smaller in size at birth compared to typically developing infants but grow larger than their peers during the first year. Little is known about their rate of growth, especially for height and weight. Our findings confirmed that infants with ASD are smaller in size at birth for head circumference (HC), height, and weight, but grow at a faster rate in HC and height than their peers from birth to 3 years.

© 2018 International Society for Autism Research, Wiley Periodicals, Inc.

PMID:29624910

DOI:10.1002/aur.1952

Early Head Growth in Infants at Risk of Autism: A Baby Siblings Research Consortium Study

Traduction: G.M.

J Am Acad Child Adolesc Psychiatry. 2014 Oct;53(10):1053-62. doi: 10.1016/j.jaac.2014.07.007. Epub 2014 Aug 7.

Croissante précoce de la tête chez les nourrissons à risque d'autisme: une étude du Consortium de recherche des frères et sœurs de bébés

Zwaigenbaum L¹, Young GS², Stone WL³, Dobkins K⁴, Ozonoff S², Brian J⁵, Bryson SE⁶, Carver LJ⁴, Hutman T⁷, Iverson JM⁸, Landa RJ⁹, Messinger D¹⁰.

Author information

• ¹University of Alberta, Edmonton, Alberta, Canada. Electronic address: lonniez@ualberta.ca.
• ²University of California, Davis.
• ³University of Washington, Seattle.
• ⁴University of California, San Diego.
• ⁵University of Toronto, Ontario, Canada.
• ⁶Dalhousie University, Halifax, Nova Scotia, Canada.
• ⁷University of California, Los Angeles.
• ⁸University of Pittsburgh.
• ⁹Kennedy Krieger Institute and Johns Hopkins School of Medicine, Baltimore.
• ¹⁰University of Miami.

Abstract

OBJECTIVE:

Although early brain overgrowth is frequently reported in autism spectrum disorder (ASD), the relationship between ASD and head circumference (HC) is less clear, with inconsistent findings from longitudinal studies that include community controls. Our aim was to examine whether head growth in the first 3 years differed between children with ASD from a high-risk (HR) sample of infant siblings of children with ASD (by definition, multiplex), HR siblings not diagnosed with ASD, and low-risk (LR) controls.
Bien que la prolifération précoce du cerveau est souvent signalée dans les troubles du spectre autistique (TSA), la relation entre l'ASD et circonférence de la tête (HC) est moins clair, avec des résultats contradictoires des études longitudinales qui incluent des contrôles communautaires. Notre objectif était d'examiner si la croissance de la tête dans les 3 premières années différait entre les enfants avec TSA à partir d'un échantillon de la fratrie infantile des enfants avec TSA (par définition, multiplex) à haut risque (HR)  et des frères et sœurs RH mais sans diagnostic de TSA, et des enfants contrôle à faible risque (LR).

METHOD:

Participants included 442 HR and 253 LR infants from 12 sites of the international Baby Siblings Research Consortium. Longitudinal HC data were obtained prospectively, supplemented by growth records. Random effects nonlinear growth models were used to compare HC in HR infants and LR infants. Additional comparisons were conducted with the HR group stratified by diagnostic status at age 3: ASD (n = 77), developmental delay (DD; n = 32), and typical development (TD; n = 333). Nonlinear growth models were also developed for height to assess general overgrowth associated with ASD.

RESULTS:

There was no overall difference in head circumference growth over the first 3 years between HR and LR infants, although secondary analyses suggested possible increased total growth in HR infants, reflected by the model asymptote. Analyses stratifying the HR group by 3-year outcomes did not detect differences in head growth or height between HR infants who developed ASD and those who did not, nor between infants with ASD and LR controls.
Il n'y avait pas de différence globale de la croissance de la circonférence de la tête au cours des 3 premières années entre les nourrissons HR et LR, même si les analyses secondaires ont suggéré une augmentation possible de la croissance totale chez les nourrissons, qui se traduit par le modèle asymptote. Les analyses stratifiant les résultats du groupe HR à 3 ans n'ont pas détecté de différences dans la croissance de la tête ou de la hauteur entre les nourrissons de RH qui ont développé un TSA et ceux qui n'en ont pas développé, ni entre les enfants avec TSA et du groupe contrôle LR.

CONCLUSION:

Head growth was uninformative as an ASD risk marker within this HR cohort.
La croissance de la tête était nin pertinente en tant que marqueur de risque de TSA dans cette cohorte à haut risque d'autisme.

Copyright © 2014 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

PMID: 25245349