Aperçu: G.M.
L'utilisation
réussie d'helminthes en tant qu'agents thérapeutiques pour résoudre la maladie inflammatoire a été rapportée pour la première fois il y a 40 ans. Ces organismes pourraient traiter efficacement un large
éventail de maladies inflammatoires, y compris des allergies, des
troubles auto-immuns et des troubles neuropsychiatriques associés à
l'inflammation. Cinq médecins surveillant plus de 700 patients auto-traitants ont été interviewés.
Environ 57% des patients auto-traitants observés par les médecins de l'étude avaient un autisme. Les
médecins ont rapporté que la majorité leurs patients avec un diagnostic de TSA et des co-morbidités associées à l'inflammation ont répondu favorablement
à la thérapie avec l'un ou l'autre des deux organismes les plus
populaires actuellement utilisés par les auto-traitements, Hymenolepis
diminuta et Trichuris suis. Cependant,
environ 1% des patients pédiatriques ont souffert de douleurs
gastro-intestinales sévères avec l'utilisation de H. diminuta, bien que
les symptômes aient été résolus avec un médicament anti-helminthique.
L'exposition
aux helminthes n'a apparemment pas affecté la compréhension réduite des
situations sociales qui est la marque distinctive de l'autisme.
J Helminthol. 2017 May;91(3):267-277. doi: 10.1017/S0022149X16000316. Epub 2016 May 31.
Practices and outcomes of self-treatment with helminths based on physicians' observations
Author information
- 1
- Department of Surgery,Duke University Medical Center,Durham, NC 27710,USA.
- 2
- Department of Psychiatry and Behavioral Sciences,Duke University Medical Center,Durham, NC 27710,USA.
- 3
- Department of Sociology,University of Central Arkansas,Conway, AR, 72035,USA.
Abstract
The
successful use of helminths as therapeutic agents to resolve
inflammatory disease was first recorded 40 years ago. Subsequent work in
animal models and in humans has demonstrated that the organisms might
effectively treat a wide range of inflammatory diseases, including
allergies, autoimmune disorders and inflammation-associated
neuropsychiatric disorders. However, available information regarding the
therapeutic uses and effects of helminths in humans is limited. This
study probes the practices and experiences of individuals
'self-treating' with helminths through the eyes of their physicians.
Five physicians monitoring more than 700 self-treating patients were
interviewed. The results strongly support previous indications that
helminth therapy can effectively treat a wide range of allergies,
autoimmune conditions and neuropsychiatric disorders, such as major
depression and anxiety disorders. Approximately 57% of the self-treating
patients observed by physicians in the study had autism. Physicians reported that the majority of patients with autism
and inflammation-associated co-morbidities responded favourably to
therapy with either of the two most popular organisms currently used by
self-treaters, Hymenolepis diminuta and Trichuris suis. However,
approximately 1% of paediatric patients experienced severe
gastrointestinal pains with the use of H. diminuta, although the
symptoms were resolved with an anti-helminthic drug. Further, exposure
to helminths apparently did not affect the impaired comprehension of
social situations that is the hallmark of autism.
These observations point toward potential starting points for clinical
trials, and provide further support for the importance of such trials
and for concerted efforts aimed at probing the potential of helminths,
and perhaps other biologicals, for therapeutic use.
- PMID: 27240605
- DOI: 10.1017/S0022149X16000316
