Aperçu: G.M.
Les
troubles du spectre de l'autisme (TSA) sont des troubles du
développement neurologique sans une étiologie irréfutable dans la plupart
des cas.
Les
facteurs environnementaux, tels que les infections virales, ont été
liés à des anomalies dans la croissance du cerveau, au développement
neuronal et à la connectivité fonctionnelle. L'infection par le cytomégalovirus congénital (CMV) a été associée à l'apparition de la TSA dans plusieurs cas. L'objectif de cette étude était d'évaluer la prévalence de l'infection
congénitale par CMV chez les enfants avec un diagnostic de TSA et chez les enfants témoins sans TSA.
Le
taux d'infection était environ 10 fois plus élevé chez les enfants avec un diagnostic de TSA que dans la population italienne en général à la
naissance. Pour
cette raison, la détection de l'ADN de CMV sur des taches de sang séché
pourrait être envisagée dans le traitement qui est habituellement
effectué au diagnostic de TSA pour exclure une forme secondaire.
In Vivo. 2017 May-Jun;31(3):467-473.
Prevalence of Congenital Cytomegalovirus Infection Assessed Through Viral Genome Detection in Dried Blood Spots in Children with Autism Spectrum Disorders
Gentile I1, Zappulo E2, Riccio MP3, Binda S4, Bubba L4, Pellegrinelli L4, Scognamiglio D5, Operto F6, Margari L6, Borgia G2, Bravaccio C7.
Author information
- 1
- Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples "Federico II", Naples, Italy ivan.gentile@unina.it.
- 2
- Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples "Federico II", Naples, Italy.
- 3
- Department of Physical and Mental Health and Preventive Medicine, Second University of Naples, Naples, Italy.
- 4
- Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
- 5
- Screening Center for Metabolic Diseases, AORN Santobono - Pausilipon - Hospital Annunziata, Naples, Italy.
- 6
- Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari "Aldo Moro", Bari, Italy.
- 7
- Department of Medical Translational Science, University of Naples "Federico II", Naples, Italy.
Abstract
BACKGROUND/AIM:
Autism spectrum disorders (ASD) are neurodevelopmental disorders without a definitive etiology in most cases. Environmental factors, such as viral infections, have been linked with anomalies in brain growth, neuronal development, and functional connectivity. Congenital cytomegalovirus (CMV) infection has been associated with the onset of ASD in several case reports. The aim of this study was to evaluate the prevalence of congenital CMV infection in children with ASD and in healthy controls.PATIENTS AND METHODS:
The CMV genome was tested by polymerase chain reaction (PCR) on dried blood spots collected at birth from 82 children (38 with ASD and 44 controls).RESULTS:
The prevalence of congenital CMV infection was 5.3% (2/38) in cases and 0% (0/44) in controls (p=0.212).CONCLUSION:
The infection rate was about 10-fold higher in patients with ASD than in the general Italian population at birth. For this reason, detection of CMV-DNA on dried blood spots could be considered in the work-up that is usually performed at ASD diagnosis to rule-out a secondary form. Given the potential prevention and treatment of CMV infection, this study could have intriguing consequences, at least for a group of patients with ASD.
Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
- PMID: 28438881
- DOI: 10.21873/invivo.11085
