Aperçu: G.M.
Les chercheurs trouvent une association entre le tabagisme de la grand-mère maternelle fumant pendant
la grossesse et le fait que les petites-filles aient des résultats défavorables dans
les mesures de communication sociale et de comportement répétitif qui
prédisent de façon indépendante le diagnostic d'autisme. Conformément à cela, ils montrent une association avec le diagnostic réel de l'autisme chez ses petits-enfants. Les grand-mère paternelles qui ont fumé pendant la grossesse n'ont pas eu d'associations.
Sci Rep. 2017 Apr 27;7:46179. doi: 10.1038/srep46179.
Grand-maternal smoking in pregnancy and grandchild's autistic traits and diagnosed autism
Golding J1, Ellis G1, Gregory S1, Birmingham K1, Iles-Caven Y1, Rai D2, Pembrey M1.
Author information
- 1
- Centre for Child and Adolescent Health, School of Social and Community Medicine, University of Bristol, Bristol, UK.
- 2
- Centre for Academic Mental Health, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Abstract
Although
there is considerable research into the genetic background of autism
spectrum disorders, environmental factors are likely to contribute to
the variation in prevalence over time. Rodent experiments indicate that
environmental exposures can have effects on subsequent generations, and
human studies indicate that parental prenatal exposures may play a part
in developmental variation. Here we use the Avon Longitudinal Study of
Parents and Children (ALSPAC) to test the hypothesis that if the mother
or father (F1) had been exposed to their own mother's (F0) smoking
during pregnancy, the offspring (F2) would be at increased risk of
autism. We find an association between maternal grandmother smoking in
pregnancy and grand daughters having adverse scores in Social
Communication and Repetitive Behaviour measures that are independently
predictive of diagnosed autism. In line with this, we show an
association with actual diagnosis of autism in her grandchildren.
Paternal grandmothers smoking in pregnancy showed no associations.
- PMID: 28448061
- DOI: 10.1038/srep46179
