Le tabagisme grand-maternel pendant la grossesse et les traits autistiques et le diagnostic d'autisme des petits-enfants

Aperçu: G.M.

Les chercheurs trouvent une association entre le tabagisme de la grand-mère maternelle fumant pendant la grossesse et le fait que les petites-filles aient des résultats défavorables dans les mesures de communication sociale et de comportement répétitif qui prédisent de façon indépendante le diagnostic d'autisme. Conformément à cela, ils montrent une association avec le diagnostic réel de l'autisme chez ses petits-enfants. Les grand-mère paternelles qui ont fumé pendant la grossesse n'ont pas eu d'associations.

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Sci Rep. 2017 Apr 27;7:46179. doi: 10.1038/srep46179.

Grand-maternal smoking in pregnancy and grandchild's autistic traits and diagnosed autism

Golding J¹, Ellis G¹, Gregory S¹, Birmingham K¹, Iles-Caven Y¹, Rai D², Pembrey M¹.

Author information

1

Centre for Child and Adolescent Health, School of Social and Community Medicine, University of Bristol, Bristol, UK.

2

Centre for Academic Mental Health, School of Social and Community Medicine, University of Bristol, Bristol, UK.

Abstract

Although there is considerable research into the genetic background of autism spectrum disorders, environmental factors are likely to contribute to the variation in prevalence over time. Rodent experiments indicate that environmental exposures can have effects on subsequent generations, and human studies indicate that parental prenatal exposures may play a part in developmental variation. Here we use the Avon Longitudinal Study of Parents and Children (ALSPAC) to test the hypothesis that if the mother or father (F1) had been exposed to their own mother's (F0) smoking during pregnancy, the offspring (F2) would be at increased risk of autism. We find an association between maternal grandmother smoking in pregnancy and grand daughters having adverse scores in Social Communication and Repetitive Behaviour measures that are independently predictive of diagnosed autism. In line with this, we show an association with actual diagnosis of autism in her grandchildren. Paternal grandmothers smoking in pregnancy showed no associations.

PMID: 28448061

DOI: 10.1038/srep46179