Caractérisation de l'utilisation des médicaments dans un échantillon multicentrique de patients hospitalisés en pédiatrie avec un diagnostic de trouble du spectre de l'autisme

Aperçu: G.M.

Près de 11% des jeunes avec un diagnostic de troubles du spectre de l'autisme (TSA) subissent une hospitalisation psychiatrique et 65% sont traités avec des médicaments psychotropes. Dans cette étude les chercheurs caractérisent l'utilisation de médicaments psychotropes chez des sujets inscrits dans l'Autism Inpatient Collection.  

Les taux d'utilisation des médicaments psychotropes par les participants ont dépassé 90% à l'admission et à la sortie, bien qu'il y ait eu un déclin au suivi de 2 mois.  

Les antipsychotiques, les médicaments contre le TDAH et les aides au sommeil étaient les classes de médicaments les plus fréquemment rapportées.  

L'impact de l'âge, du sexe et du QI non verbal sur les taux d'utilisation des médicaments était minime, même si l'âge et le QI peuvent jouer un rôle dans les pratiques de prescription.

J Autism Dev Disord. 2017 May 17. doi: 10.1007/s10803-017-3153-x.

Characterization of Medication Use in a Multicenter Sample of Pediatric Inpatients with Autism Spectrum Disorder

Wink LK¹, Pedapati EV², Adams R³, Erickson CA², Pedersen KA⁴, Morrow EM⁵, Kaplan D⁶, Siegel M⁷; Autism and Developmental Disorders Inpatient Research Collaborative (ADDIRC).

Collaborators (52)

Siegel M, Erickson C, Gabriels RL, Kaplan D, Mazefsky C, Morrow EM, Righi G, Santangelo SL, Wink L, Benevides J, Beresford C, Best C, Bowen K, Dechant B, Flis T, Gastgeb H, Geer A, Hagopian L, Handen B, Klever A, Lubetsky M, MacKenzie K, Meservy Z, McGonigle J, McGuire K, McNeil F, Montrenes J, Palka T, Pedapati E, Pedersen KA, Peura C, Pierri J, Rogers C, Rossman B, Ruberg J, Sannar E, Small C, Stuckey N, Tylenda B, Verdi M, Vezzoli J, Williams D, Williams D, Germain DLS, Robinson G, Kasari C, King B, McCracken J, McDougle C, Scahill L, Schultz R, Tager-Flusberg H.

Author information

1

Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave MLC 4002, Cincinnati, OH, 45229, USA. logan.wink@cchmc.org.

2

Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave MLC 4002, Cincinnati, OH, 45229, USA.

3

Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave MLC 4002, Cincinnati, OH, 45229, USA.

4

Maine Medical Center Research Institute, Tufts University School of Medicine, 509 Forest Avenue, Portland, ME, 04101, USA.

5

Emma Pendleton Bradley Hospital, Rhode Island Consortium for Autism Research and Treatment (RI-CART), and the Hassenfeld Child Health Innovation Institute, Alpert Medical School of Brown University, 1011 Veterans Memorial Pkwy., East Providence, RI, 02915, USA.

6

Sheppard Pratt Health System, University of Maryland School of Medicine, 6501 N. Charles Street, Baltimore, MD, 21204, USA.

7

Maine Medical Center Research Institute, Spring Harbor Hospital, Tufts University School of Medicine, 123 Andover Road, Westbrook, ME, 04092, USA.

Abstract

Nearly 11% of youth with Autism Spectrum Disorder (ASD) undergo psychiatric hospitalization, and 65% are treated with psychotropic medication. Here we characterize psychotropic medication usage in subjects enrolled in the Autism Inpatient Collection. Participant psychotropic medication usage rates topped 90% at admission and discharge, though there was a decline at 2-month follow-up. Antipsychotics, ADHD medications, and sleep aids were the most commonly reported classes of medications. The impact of age, gender, and non-verbal IQ on medication usage rates was minimal, though age and IQ may play a role in prescribing practices. Future work is indicated to explore medication usage trends, the impact of clinical factors on medication use rates, and the safety of psychotropic medications in youth with ASD.

PMID: 28516426

DOI: 10.1007/s10803-017-3153-x