Augmentation des niveaux de zonuline sérique comme marqueur de perméabilité intestinale chez les sujets autistes

Aperçu: G.M.

Le but de cette étude était d'évaluer les taux sériques de zonuline, qui régule les jonctions étroites entre les entérocytes et est un modulateur physiologique qui contrôle la perméabilité intestinale, chez les patients avec un diagnostic de trouble du spectre de l'autisme.

Les taux de zonuline sérique étaient significativement plus élevés chez les patients avec un diagnostic de TSA (122,3 ± 98,46 ng / mL) que chez les témoins sans autisme (41,89 ± 45,83 ng / mL). 

Il y a eu une corrélation positive entre les niveaux de zonuline et le score CARS lorsque tous les sujets ont été évalués (r = 0,523; P <0,001).Cette étude suggère que la zonuline, qui régule la perméabilité intestinale, joue un rôle dans le développement des symptômes du TSA. 

J Pediatr. 2017 May 11. pii: S0022-3476(17)30487-0. doi: 10.1016/j.jpeds.2017.04.004.

Increased Serum Zonulin Levels as an Intestinal Permeability Marker in Autistic Subjects

Esnafoglu E¹, Cırrık S², Ayyıldız SN³, Erdil A⁴, Ertürk EY⁴, Daglı A⁴, Noyan T³.

Author information

1

Faculty of Medicine, Research and Training Hospital, Department of Child and Adolescent Psychiatry, Ordu University, Ordu, Turkey. Electronic address: ermanesnafoglu@yahoo.com.tr

2

Faculty of Medicine, Department of Medical Physiology, Ordu University, Ordu, Turkey.

3

Faculty of Medicine, Research and Training Hospital, Department of Biochemistry, Ordu University, Ordu, Turkey.

4

Department of Pediatrics, Faculty of Medicine, Research and Training Hospital, Department of Pediatry, Ordu University, Ordu, Turkey.

Abstract

OBJECTIVE:

To evaluate the serum levels of zonulin, which regulates tight junctions between enterocytes and is a physiological modulator controlling intestinal permeability, in patients with autism spectrum disorders (ASDs).

STUDY DESIGN:

Serum zonulin levels were determined in 32 patients with ASD and 33 healthy controls using an enzyme-linked immunosorbent assay. The severity of ASD symptoms was assessed with the Childhood Autism Rating Scale.

RESULTS:

Serum zonulin levels were significantly higher in the patients with ASD (122.3 ± 98.46 ng/mL) compared with the healthy controls (41.89 ± 45.83 ng/mL). There was a positive correlation between zonulin levels and Childhood Autism Rating Scale score when all subjects were assessed (r = 0.523; P < .001).

CONCLUSIONS:

This study suggests that zonulin, which regulates intestinal permeability, plays a role in the development of symptoms of ASD.

Copyright © 2017 Elsevier Inc. All rights reserved.

PMID: 28502607

DOI: 10.1016/j.jpeds.2017.04.004