Concentration urinaire des métabolites des insecticides organophosphorés pendant la grossesse et comportement interpersonnel, communication, répétitif et stéréotypé des enfants à l'âge de 8 ans: l'étude à domicile

Aperçu: G.M.

L'exposition prénatale aux insecticides organophosphorés peut être associée à des troubles du spectre de l'autisme et à des comportements connexes. Cette association peut être modifiée par des polymorphismes nucléotidiques simples dans l'enzyme de la paraoxonase (PON1).

 Parmi 224 femmes enceintes, les chercheurs ont quantifié les concentrations de six métabolites non spécifiques du phosphate de dialkyle (DAP) des insecticides organophosphorés dans deux échantillons d'urine recueillis à ~ 16 et ~ 26 semaines de gestation.  

Lorsque les enfants avaient huit ans, les chercheurs leur ont fait passé l'échelle de réceptivité sociale (SRS), une mesure continue de diverses dimensions du comportement interpersonnel, de la communication et des comportements répétitifs / stéréotypés. Ils ont ensuite estimé l'association entre une augmentation de 10 fois de la somme de six concentrations de DAP (ΣDAP) et les scores de SRS. ILs ont enfin examiné si les génotypes enfants PON1192 et PON1-108 ont modifié cette association.

Après l'ajustement covariable, les concentrations de ΣDAP n'ont pas été associées aux scores SRS  

Environ Res. 2017 May 10;157:9-16. doi: 10.1016/j.envres.2017.05.008.

Urinary organophosphate insecticide metabolite concentrations during pregnancy and children's interpersonal, communication, repetitive, and stereotypic behaviors at 8 years of age: The home study

Millenson ME¹, Braun JM², Calafat AM³, Barr DB⁴, Huang YT⁵, Chen A⁶, Lanphear BP⁷, Yolton K⁸.

Author information

1

Department of Epidemiology, Brown University, Providence, RI 02912, USA.

2

Department of Epidemiology, Brown University, Providence, RI 02912, USA. Electronic address: joseph_braun_1@brown.edu.

3

Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.

4

Department of Environmental Health, Emory University, Atlanta, GA, USA.

5

Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.

6

Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.

7

Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.

8

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Abstract

BACKGROUND:

Prenatal exposure to organophosphate insecticides may be associated with autism spectrum disorders and related behaviors. This association may be modified by single nucleotide polymorphisms in the paraoxonase (PON1) enzyme.

OBJECTIVE:

We examined the relationship of prenatal organophosphate insecticide biomarkers with reciprocal social, repetitive, and stereotypic behaviors in 8-year old children, and modification of this relationship by child PON1 polymorphisms.

METHODS:

Among 224 pregnant women, we quantified concentrations of six nonspecific dialkyl phosphate (DAP) metabolites of organophosphate insecticides in two urine samples collected at ~16 and ~26 weeks gestation. When children were eight years old, we administered the Social Responsiveness Scale (SRS), a continuous measure of various dimensions of interpersonal behavior, communication, and repetitive/stereotypic behaviors. We estimated the association between a 10-fold increase in the sum of six DAP concentrations (ΣDAP) and SRS scores. We examined whether child PON1₁₉₂ and PON1_-108 genotypes modified this association.

RESULTS:

After covariate adjustment, ΣDAP concentrations were not associated with SRS scores [β=-1.2; 95% confidence interval (CI): -4.0, 1.6]. Among children with the PON1_-108TT genotype, ΣDAP concentrations were associated with 2.5-point higher (95% CI: -4.9, 9.8) SRS scores; however, the association was not different from the 1.8-point decrease (95% CI: -5.8, 2.2) among children with PON1_-108CT/CC genotypes (ΣDAP × PON1_-108 p-value =0.54). The association between ΣDAP concentrations and SRS scores was not modified by PON1₁₉₂ (ΣDAP × PON1₁₉₂ p-value =0.89).

CONCLUSIONS:

In this cohort, prenatal urinary DAP concentrations were not associated with children's social behaviors; these associations were not modified by child PON1 genotype.

Copyright © 2017 Elsevier Inc. All rights reserved.

PMID: 28501654

DOI: 10.1016/j.envres.2017.05.008