Facteurs néonatals chez les sujets diagnostiqués avec un trouble envahissant du développement aux États-Unis

Aperçu: G.M.

Des études contradictoires suggèrent que certains facteurs néonatals peuvent être associés à un diagnostic de trouble envahissant du développement (TED), mais des données limitées sont disponibles à partir d'évaluations longitudinales et prospectives des dossiers médicaux.

Cette étude indique que les cas diagnostiqués avec un TED par rapport aux témoins n'ont pas de différences significatives dans les facteurs néonatals 

J Matern Fetal Neonatal Med. 2017 May 2:1-18. doi: 10.1080/14767058.2017.1326096.

Neonatal Factors among Subjects Diagnosed with a Pervasive Developmental Disorder in the US

Geier DA^1,2, Kern JK^1,2,3, Geier MR^1,2.

Author information

1

a The Institute of Chronic Illnesses, Inc , 14 Redgate Ct , Silver Spring , MD 20905 , USA.

2

b CoMeD, Inc , 14 Redgate Ct , Silver Spring , MD 20905 , USA.

3

c CONEM US Autism Research Group , 408 N Allen Dr. , Allen , TX 75013 , USA.

Abstract

PURPOSE:

Contradictory studies suggest that some neonatal factors may be associated with a pervasive developmental disorder (PDD) diagnosis, but limited data is available from longitudinal, prospective medical record assessments.

MATERIALS AND METHODS:

The present hypothesis-testing longitudinal, case-control study evaluated birth characteristics among cases diagnosed with a PDD in comparison to controls by examining prospectively collected automated medical records within the Vaccine Safety Datalink (VSD) database.

RESULTS:

Cases were Health Maintenance Organization (HMO)-enrolled from birth until diagnosed with International Classification of Disease, 9^th revision (ICD-9) PDD (299.xx) and controls were HMO-enrolled from birth for at least 4.75 years without a PDD diagnosis. The birth characteristics examined included: gender, gestational age in weeks at birth, mean birth weight in grams, Appearance-Pulse-Grimace-Activity-Respiration (APGAR) scores at 1 minute and 5 minutes, and maternal age in years at birth. Cases had a significantly increased male/female ratio relative to controls. By contrast, mean gestational age at birth, mean birth weight, mean maternal age at birth, and mean APGAR scores at 1 minute and 5 minutes were not statistical different among cases compared to controls.

CONCLUSION:

This study indicates that cases diagnosed with a PDD as compared to controls do not have significant differences in neonatal factors.

PMID: 28462601

DOI: 10.1080/14767058.2017.1326096