Le rôle du système vasopressine antioxydine / arginine dans les modèles animaux du "trouble du spectre de l'autisme"

Aperçu: G.M.

L'ocytocine non peptide (OXT) et l'arginine vasopressine (AVP) sont deux médiateurs clés dans la régulation de divers aspects des comportements sociaux des mammifères. Il existe des preuves selon lesquelles des variantes génétiques du système OXT / AVP existent dans le "trouble du spectre de l'autisme" (TSA) et que ce système est dysfonctionnel au moins dans certaines entités TSA.  Ces résultats ont stimulé l'intérêt d'effectuer des études testant l'application thérapeutique potentielle d'OXT / AVP dans les TSA. D'après les résultats des modèles animaux qui montrent des altérations du système OXT / AVP, on a laissé entendre que l'administration à dose unique ou multiple ou la stimulation de la libération endogène peuvent améliorer plusieurs déficits sociaux. Les chercheurs examinent de manière exhaustive le rôle du système OXT / AVP dans la reconnaissance sociale, l'interaction sociale et le comportement maternel à la lumière des différents modèles animaux ASD et des études sur les patients. Leur étude porte davantage sur les implications pour les interventions pharmacologiques liées à l'OXT / AVP pour atténuer les déficits sociaux dans les TSA dans le futur.

 

Adv Anat Embryol Cell Biol. 2017;224:135-158. doi: 10.1007/978-3-319-52498-6_8.

The Role of the Oxytocin/Arginine Vasopressin System in Animal Models of Autism Spectrum Disorder

Zhang R^1,2,3, Xu XJ^4,5,6,7, Zhang HF^4,5,6,8, Han SP⁹, Han JS^4,5,6.

Author information

1

Neuroscience Research Institute, Peking University, Beijing, China. zhangrong@bjmu.edu.cn

2

Department of Neurobiology, Health Science Center, School of Basic Medical Sciences, Peking University, Beijing, China. zhangrong@bjmu.edu.cn

3

Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing, China. zhangrong@bjmu.edu.cn.

4

Neuroscience Research Institute, Peking University, Beijing, China.

5

Department of Neurobiology, Health Science Center, School of Basic Medical Sciences, Peking University, Beijing, China.

6

Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing, China.

7

Department of Scientific Research, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

8

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Collaborative Innovation Center for Brain Science, Xiamen University, Xiamen, China.

9

Wuxi shenpingxintai Medical Technology Co., Ltd., Wuxi, China.

Abstract

The nonapeptides oxytocin (OXT) and arginine vasopressin (AVP) are two key mediators in regulating various aspects of mammalian social behaviours. There are several lines of evidence that genetic variants of the OXT/AVP system exist in autism spectrum disorder (ASD) and that this system is dysfunctional at least in some ASD entities. These findings have stimulated the interest to perform studies testing the potential therapeutic application of OXT/AVP in ASD. In this respect animal models are critical for investigating the pathophysiology and for compound screening leading to new therapeutic approaches. Based on findings in animal models that show alterations of the OXT/AVP system, it has been hypothesised that single- or multiple-dose administration or the stimulation of endogenous release can improve several social deficits. Here we comprehensively review the role of the OXT/AVP system in social recognition, social interaction and maternal behaviour in the light of different ASD animal models and patient studies. We further discuss implications for OXT/AVP-related pharmacological interventions to alleviate social deficits in ASD in the future.

PMID:28551755

DOI:10.1007/978-3-319-52498-6_8