Méta-analyse à l'échelle du génome de l'empathie cognitive: héritabilité et corrélée au sexe, aux troubles neuropsychiatriques et à la cognition

Aperçu: G.M.

L'équipe a mené une méta-analyse du génome de l'empathie cognitive en utilisant le test «Lecture de l'esprit dans le regard» chez 88 056 bénévoles d'ascendance européenne (44 574 femmes et 43 482 hommes). Ils ont confirmé un avantage féminin sur le test des yeux (Cohen's d = 0,21, P <2,2 × 10-16) et identifié un locus dans 3p26.1 qui est associé à des scores sur le test des yeux chez les femmes.

Les polymorphismes nucléotidiques simples ont expliqué 5,8% (IC 95%: 4,5% -7,2%; P = 1,00 × 10-17) de la variance totale des caractères chez les deux sexes et l'équipe a identifié une héritabilité de 28% chez les jumeaux(IC 95%: 13 % -42%). Enfin, elle a identifié une corrélation génétique significative entre le test des yeux et l'anorexie mentale, l'ouverture (Inventaire du facteur NEO-Five) et différentes mesures du niveau de scolarité et de l'aptitude cognitive. 

Mol Psychiatry. 2017 Jun 6. doi: 10.1038/mp.2017.122.

Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition

Warrier V¹, Grasby KL², Uzefovsky F^1,3, Toro R^4,5,6, Smith P¹, Chakrabarti B⁷, Khadake J⁸, Mawbey-Adamson E⁸, Litterman N⁹, Hottenga JJ^10,11,12, Lubke G¹³, Boomsma DI¹⁰, Martin NG², Hatemi PK¹⁴, Medland SE², Hinds DA⁹, Bourgeron T^4,5,6, Baron-Cohen S^1,15.

Author information

1

Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridgeshire, UK.

2

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

3

Department of Psychology, Ben Gurion University of the Negev, Be'er Sheva, Israel.

4

CNRS UMR 3571: Genes, Synapses and Cognition, Institut Pasteur, Paris, France.

5

Université Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, Paris, France.

6

Institut Pasteur, Paris, France.

7

Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.

8

NIHR Cambridge BioResource, Cambridge University and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

9

23andMe Inc., Mountain View, CA, USA.

10

Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

11

EMGO+ Institute for Health and Care Research, VU Medical Center, Amsterdam, The Netherlands.

12

Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

13

Department of Psychology, University of Notre Dame, South Bend, IN, USA.

14

Political Science, Microbiology and Biochemistry, Pennsylvania State University, University Park, PA, USA.

15

CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust (CPFT), Cambridgeshire, UK.

Abstract

We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe Inc., and an additional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane Longitudinal Twin Study. We confirmed a female advantage on the Eyes Test (Cohen's d=0.21, P<2.2 × 10^-16), and identified a locus in 3p26.1 that is associated with scores on the Eyes Test in females (rs7641347, P_meta=1.58 × 10^-8). Common single nucleotide polymorphisms explained 5.8% (95% CI: 4.5%-7.2%; P=1.00 × 10^-17) of the total trait variance in both sexes, and we identified a twin heritability of 28% (95% CI: 13%-42%). Finally, we identified significant genetic correlation between the Eyes Test and anorexia nervosa, openness (NEO-Five Factor Inventory), and different measures of educational attainment and cognitive aptitude.Molecular Psychiatry advance online publication, 6 June 2017; doi:10.1038/mp.2017.122.

PMID:28584286

DOI:10.1038/mp.2017.122