30 mars 2017

La variabilité accrue de la force est associée à une modification de la modulation de l'activité de l'activité d'ensemble de motoneurones dans le trouble du spectre de l'autisme

Aperçu: G.M.
Les déficits de contrôle de la force ont été documentés à plusieurs reprises dans le trouble du spectre de l'autisme (TSA). Ils sont associés à une plus grande détérioration des habiletés sociales et de la vie quotidienne chez les personnes, ce qui suggère que développer une compréhension plus mécanique des processus centraux et périphériques qui les causent peut aider à guider le développement de traitements qui améliorent les résultats multiples dans le TSA.
Les personnes avec un diagnostic de TSA présentaient une plus grande variabilité de force que les témoins lorsqu'ils essayaient de maintenir une force constante. Ces résultats suggèrent que des altérations des mécanismes centraux qui contrôlent le déclenchement d'ensembles de motoneurones peuvent sous-tendre les symptômes communs et souvent invalidants des TSA.


Int J Mol Sci. 2017 Mar 25;18(4). pii: E698. doi: 10.3390/ijms18040698.

Increased Force Variability Is Associated with Altered Modulation of the Motorneuron Pool Activity in Autism Spectrum Disorder (ASD)

Wang Z1,2,3, Kwon M4,5,6, Mohanty S7, Schmitt LM8,9,10, White SP11, Christou EA12, Mosconi MW13,14,15.

Author information

1
Schiefelbusch Institute for Life Span Studies, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. zhengwang@ku.edu
2
Clinical Child Psychology Program, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. zhengwang@ku.edu.
3
Kansas Center for Autism Research and Training (K-CART), University of Kansas Medical School, Overland Park, KS 66213, USA. zhengwang@ku.edu.
4
Schiefelbusch Institute for Life Span Studies, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. minhyuk.kwon@marquette.edu.
5
Clinical Child Psychology Program, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. minhyuk.kwon@marquette.edu.
6
Kansas Center for Autism Research and Training (K-CART), University of Kansas Medical School, Overland Park, KS 66213, USA. minhyuk.kwon@marquette.edu.
7
Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. smohanty3@humana.com.
8
Schiefelbusch Institute for Life Span Studies, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. lmschmitt@ku.edu.
9
Clinical Child Psychology Program, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. lmschmitt@ku.edu.
10
Kansas Center for Autism Research and Training (K-CART), University of Kansas Medical School, Overland Park, KS 66213, USA. lmschmitt@ku.edu.
11
Center for Autism and Developmental Disabilities, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Stormi.White@UTsouthwestern.edu.
12
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. eachristou@hhp.ufl.edu.
13
Schiefelbusch Institute for Life Span Studies, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. mosconi@ku.edu.
14
Clinical Child Psychology Program, University of Kansas, 1000 Sunnyside Ave., Lawrence, KS 66045, USA. mosconi@ku.edu.
15
Kansas Center for Autism Research and Training (K-CART), University of Kansas Medical School, Overland Park, KS 66213, USA. mosconi@ku.edu.

Abstract

Force control deficits have been repeatedly documented in autism spectrum disorder (ASD). They are associated with worse social and daily living skill impairments in patients suggesting that developing a more mechanistic understanding of the central and peripheral processes that cause them may help guide the development of treatments that improve multiple outcomes in ASD. The neuromuscular mechanisms underlying force control deficits are not yet understood. Seventeen individuals with ASD and 14 matched healthy controls completed an isometric index finger abduction test at 60% of their maximum voluntary contraction (MVC) during recording of the first dorsal interosseous (FDI) muscle to determine the neuromuscular processes associated with sustained force variability. Central modulation of the motorneuron pool activation of the FDI muscle was evaluated at delta (0-4 Hz), alpha (4-10 Hz), beta (10-35 Hz) and gamma (35-60 Hz) frequency bands. ASD patients showed greater force variability than controls when attempting to maintain a constant force. Relative to controls, patients also showed increased central modulation of the motorneuron pool at beta and gamma bands. For controls, reduced force variability was associated with reduced delta frequency modulation of the motorneuron pool activity of the FDI muscle and increased modulation at beta and gamma bands. In contrast, delta, beta, and gamma frequency oscillations were not associated with force variability in ASD. These findings suggest that alterations of central mechanisms that control motorneuron pool firing may underlie the common and often impairing symptoms of ASD.
PMID: 28346344
DOI: 10.3390/ijms18040698

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