Aperçu : G.M.
Un nouveau mécanisme génétique de perte du facteur cellulaire dendritique 1 (Dcf1) dans le système
nerveux de la souris induit une carence en interaction sociale, comme dans l'autisme et influence l'interaction sociale via le
système dopamine.
Behav Brain Res. 2017 May 1;324:51-57. doi: 10.1016/j.bbr.2017.01.045. Epub 2017 Feb 13.
Dopamine and dopamine receptor D1 associated with decreased social interaction
Author information
- 1
- Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
- 2
- Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China. Electronic address: wtq@shu.edu.cn
Abstract
Deficits
in social interaction are hallmarks of neurological and psychiatric
disorders. However, its underlying mechanism is still unclear. Here, we
show that the loss of dendritic cell factor 1 (Dcf1) in the nervous
system of mice induces social interaction deficiency, autism-like
behaviour, and influences social interaction via the dopamine system.
Dopamine receptor D1 agonist rescues this social cognition phenotype,
and improves short-term plasticity. Together, this study presents a new
genetic mechanism that affects social interaction and may provide a new
way to improve positive social interaction and treat autism spectrum disorders.
Copyright © 2017 Elsevier B.V. All rights reserved.
- PMID: 28202411
- DOI:10.1016/j.bbr.2017.01.045
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