14 mars 2017

Dopamine et le récepteur de la dopamine D1 associés à une interaction sociale réduite

Aperçu : G.M.
Un nouveau mécanisme génétique de perte du facteur cellulaire dendritique 1 (Dcf1) dans le système nerveux de la souris induit une carence en interaction sociale, comme dans l'autisme et influence l'interaction sociale via le système dopamine.
 
 
Behav Brain Res. 2017 May 1;324:51-57. doi: 10.1016/j.bbr.2017.01.045. Epub 2017 Feb 13.

Dopamine and dopamine receptor D1 associated with decreased social interaction

Author information

1
Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China.
2
Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 333 Nanchen Road, Shanghai, 200444, China. Electronic address: wtq@shu.edu.cn

Abstract

Deficits in social interaction are hallmarks of neurological and psychiatric disorders. However, its underlying mechanism is still unclear. Here, we show that the loss of dendritic cell factor 1 (Dcf1) in the nervous system of mice induces social interaction deficiency, autism-like behaviour, and influences social interaction via the dopamine system. Dopamine receptor D1 agonist rescues this social cognition phenotype, and improves short-term plasticity. Together, this study presents a new genetic mechanism that affects social interaction and may provide a new way to improve positive social interaction and treat autism spectrum disorders.
PMID: 28202411
DOI:10.1016/j.bbr.2017.01.045

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