Aperçu: G.M.
Les
études de neuroimagerie dans les troubles du spectre de l'autisme (TSA)
ont fourni des preuves incohérentes d'anomalies corticales. Cela
s'explique probablement par la faible taille des échantillons utilisés
dans la plupart des études et par les différences importantes dans les
caractéristiques de l'échantillon, notamment l'âge, ainsi que
l'hétérogénéité du trouble.
Les résultats montrent une augmentation de l'épaisseur corticale dans
le TSA, principalement latéralisé à gauche, à partir de 6 ans, avec des
différences diminuant au cours de l'âge adulte. La gravité des symptômes liés à l'affect social et la communication est corrélée avec ces anomalies corticales.
Cereb Cortex. 2017 Feb 18:1-11. doi: 10.1093/cercor/bhx038.
Cortical Thickness Abnormalities in Autism Spectrum Disorders Through Late Childhood, Adolescence, and Adulthood: A Large-Scale MRI Study
Khundrakpam BS1, Lewis JD1, Kostopoulos P1, Carbonell F1, Evans AC1.
Author information
- 1
- Montreal Neurological Institute, McGill University, Montreal, QC, CanadaH3H2P1.
Abstract
Neuroimaging studies in autism
spectrum disorders (ASDs) have provided inconsistent evidence of
cortical abnormality. This is probably due to the small sample sizes
used in most studies, and important differences in sample
characteristics, particularly age, as well as to the heterogeneity of
the disorder. To address these issues, we assessed abnormalities in ASD within the Autism
Brain Imaging Data Exchange data set, which comprises data from
approximately 1100 individuals (~6-55 years). A subset of these data
that met stringent quality control and inclusion criteria (560 male
subjects; 266 ASD; age = 6-35 years) were used to compute age-specific
differences in cortical thickness in ASD and the relationship of any
such differences to symptom severity of ASD. Our results show widespread
increased cortical thickness in ASD, primarily left lateralized, from 6
years onwards, with differences diminishing during adulthood. The
severity of symptoms related to social affect and communication
correlated with these cortical abnormalities. These results are
consistent with the conjecture that developmental patterns of cortical
thickness abnormalities reflect delayed cortical maturation and
highlight the dynamic nature of morphological abnormalities in ASD.
© The Author 2017. Published by Oxford University Press.For Permissions, please e-mail: journals.permissions@oup.com.
- PMID: 28334080
- DOI: 10.1093/cercor/bhx038
Aucun commentaire:
Enregistrer un commentaire