Aperçu: G.M.
Les
données obtenues démontrent une élévation significative du Hg et du Pb
ainsi qu'une diminution significative des taux de Se dans les globules
rouges des patients avec TSA par rapport aux témoins sans TSA.
Metab Brain Dis. 2017 Mar 21. doi: 10.1007/s11011-017-9996-1.
Relationship between selenium, lead, and mercury in red blood cells of Saudi autistic children
El-Ansary A1,2,3, Bjørklund G4, Tinkov AA5,6,7, Skalny AV6,7,8,9, Al Dera H10,11.
Author information
- 1
- Central Laboratory, Center for Female Scientific and Medical Colleges, King Saud University, Riyadh, Saudi Arabia.
- 2
- Autism Research and Treatment Center, Riyadh, Saudi Arabia.
- 3
- Medicinal Chemistry Department, National Research Centre, Dokki, Cairo, Egypt.
- 4
- Council for Nutritional and Environmental Medicine, Toften 24, 8610, Mo i Rana, Norway. bjorklund@conem.org.
- 5
- Orenburg State University, Orenburg, Russia.
- 6
- Orenburg State Medical University, Orenburg, Russia.
- 7
- Yaroslavl State University, Yaroslavl, Russia.
- 8
- RUDN University, Moscow, Russia.
- 9
- All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russia.
- 10
- Basic Medical Science Department, College of Medicine, King Saud bin Abdul Aziz University for Health Sciences, Riyadh, Saudi Arabia.
- 11
- King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder
that can cause significant social, communication and behavioral
challenges. Environmental contribution to ASD is due in large part to
the sensitivity of the developing brain to external exposures such as
lead (Pb), and mercury (Hg) as toxic heavy metals or due to a poor
detoxification ability as the phenotype of this disorder.
Selenium (Se) as an antioxidant element that counteracts the
neurotoxicity of Hg, and Pb, presumably through the formation of
nontoxic complexes. In the present study, Pb, Hg, and Se were measured
in red blood cells (RBCs) of 35 children with ASD and 30 age- and
gender-matched healthy control children using atomic absorption
spectrometry. Receiver Operating Characteristics (ROC) analysis of the
obtained data was performed to measure the predictive value of their
absolute and relative concentrations. The obtained data demonstrates a
significant elevation of Hg and Pb together with a significant decrease
in the Se levels in RBCs of patients with ASD when compared to the
healthy controls. The ratios of Se to both Pb and Hg were remarkably
altered, being indicative of heavy metal neurotoxicity in patients with
ASD. In conclusion, the present study indicates the importance of Se for
prevention and/or therapy of heavy metal neurotoxicity.
- PMID: 28326463
- DOI: 10.1007/s11011-017-9996-1
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