Aperçu: G.M.
La régression linguistique (RL) est un phénomène constant et reproductible signalé par environ 25% des parents d'enfants ayant un diagnostic de "trouble du spectre de l'autisme" (dTSA). Cependant, il existe une controverse concernant la signification étiologique et clinique de ce phénomène.
Ici, nous avons examiné les données d'une cohorte de 218 enfants avec un dTSA du Negev Autism Centre en Israël. Nous avons identifié 36 enfants avec un dTSA chez qui, à trois reprises, leurs parents avaient clairement signalé leur RL et les avons comparés à 104 enfants dont les parents n’ont signalé aucun problème de régression (NR).
Nous avons comparé diverses caractéristiques de développement clés parmi ces deux groupes. Nous avons constaté que l'âge auquel les enfants avec un dTSA du groupe LR atteignaient des étapes clés du développement, à savoir ramper, marcher et utiliser les premiers mots, est nettement plus jeune que l'âge des enfants du groupe NR et comparable à l'âge des enfants en développement typique . En revanche, aucune différence n'a été observée dans les caractéristiques de croissance physique telles que le tour de tête, le poids ou la taille entre les groupes. En outre, presque tous les enfants atteints de RL sont nés près de la fin de leur vie (> 35 semaines) et aucun d'entre eux n'avait d'antécédents d'hypotonie. En particulier, malgré leur développement précoce apparemment typique, on a diagnostiqué chez les enfants RL des symptômes de TSA plus graves que chez les enfants NR.
Ces résultats renforcent la motivation à poursuivre et à étudier le RL chez les enfants avec un dTSA et suggèrent que la stratification des enfants dans les groupes de RL et de NR pourrait tirer profit des études de dépistage précoce et d'intervention.
Autism Res. 2019 Aug 30. doi: 10.1002/aur.2197.
Language regression is associated with faster early motor development in children with autism spectrum disorder
Manelis L1,2, Meiri G3, Ilan M1,3, Flusser H4, Michaelovski A4, Faroy M3, Kerub O5, Dinstein I1,2,6, Menashe I2,7.
Author information
- 1
- Psychology Department, Ben Gurion University, Beer Sheva, Israel.
- 2
- Zlotowski Center for Neuroscience, Ben Gurion University, Beer Sheva, Israel.
- 3
- Pre-School Psychiatry Unit, Soroka University Medical Center, Beer Sheva, Israel.
- 4
- Zusman Child Development Center, Soroka University Medical Center, Beer Sheva, Israel.
- 5
- Ministry of Health, Jerusalem, Israel.
- 6
- Cognitive and Brain Sciences Department, Ben Gurion University, Beer Sheva, Israel.
- 7
- Public Health Department, Ben Gurion University, Beer Sheva, Israel.
Abstract
Language regression (LR) is a consistent and reproducible phenomenon that is reported by ~25% of parents who have children with autism spectrum disorder
(ASD). However, there is controversy regarding the etiological and
clinical significance of this phenomenon. Here, we examined data from a
cohort of 218 children with ASD from the Negev Autism
Center in Israel. We identified 36 children with ASD who were reported
to exhibit clear LR by their parent on three independent occasions and
compared them to 104 children whose parents did not report any concern
of regression (NR). We compared a variety of key developmental
characteristics across these two groups. We found that the age at which
children with ASD in the LR group achieve key developmental milestones
of crawling, walking, and use of first words is significantly younger
than the age of children in the NR group, and comparable to the age of
typically developing children. In contrast, no differences were observed
in physical growth characteristics such as head circumference, weight,
or height between the groups. Furthermore, almost all children with LR
were born close to full term (>35 weeks) and none had a history of
hypotonia. Notably, despite their apparently typical early development,
children with LR were diagnosed with more severe symptoms of ASD than
children with NR. These results strengthen the motivation to continue
and study LR among children with ASD and suggest that early detection
and intervention studies of ASD may benefit from stratifying children
into LR and NR groups. Autism Res 2019, 1-12. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The presence of language regression (LR) among children with autism is still a matter of scientific debate. Here, we show that children with autism
and reported LR start to crawl, talk, and walk at the same age as other
typically developing children and significantly earlier than other
children with autism.
These findings, along with other medical differences between these
groups, suggest that children who experienced LR comprise a distinct
subgroup within the autism spectrum.
© 2019 International Society for Autism Research, Wiley Periodicals, Inc.
- PMID:31468744
- DOI:10.1002/aur.2197
