Association des troubles du spectre de l'auitisme et des maladies inflammatoires de l'intestin

Aperçu: G.M.

Les troubles du spectre autistique (TSA) et les maladies inflammatoires de l'intestin (MII) ont tous deux une pathogenèse multifactorielle avec un nombre croissant d'études démontrant des associations intestin-cerveau.

Les enfants avec un diagnostic de TSA étaient plus susceptibles de répondre aux critères de la maladie de Crohn (MC) et de la colite ulcéreuse (CU) comparativement aux témoins. Cette prévalence plus élevée de CD et UC chez les enfants avec un diagnostic de TSA par rapport aux contrôles confirme l'association du TSA avec les MII. 

J Autism Dev Disord. 2017 Nov 23. doi: 10.1007/s10803-017-3409-5.

Association of Autism Spectrum Disorders and Inflammatory Bowel Disease

Lee M^1,2,3, Krishnamurthy J⁴, Susi A⁴, Sullivan C⁴, Gorman GH⁴, Hisle-Gorman E⁴, Erdie-Lalena CR⁴, Nylund CM⁴.

Author information

1

Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. maunoolee@gmail.com.

2

, 34800 Bob Wilson Dr, San Diego, CA, 92134, USA. maunoolee@gmail.com.

3

Internal Medicine, Naval Medical Center, San Diego, CA, USA. maunoolee@gmail.com.

4

Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Abstract

Autism spectrum disorders (ASD) and inflammatory bowel disease (IBD) both have multifactorial pathogenesis with an increasing number of studies demonstrating gut-brain associations. We aim to examine the association between ASD and IBD using strict classification criteria for IBD. We conducted a retrospective case-cohort study using records from the Military Health System database with IBD defined as having one encounter with an ICD-9-CM diagnostic code for IBD and at least one outpatient prescription dispensed for a medication to treat IBD. Children with ASD were more likely to meet criteria for Crohn's disease (CD) and Ulcerative colitis (UC) compared to controls. This higher prevalence of CD and UC in children with ASD compared to controls confirms the association of ASD with IBD.

PMID:29170940

DOI:10.1007/s10803-017-3409-5