Aperçu: G.M.
Des
études récentes suggèrent que les résultats de longue date sur la
morphologie anormale de l'amygdale dans le TSA peut être liée aux
symptômes de l'anxiété. Pour
tester cette hypothèse, cinquante-trois enfants avec un diagnostic de TSA (âge
moyen = 11,9) ont subi une IRM structurale et ont été divisés en
sous-groupes pour comparer ceux avec au moins un diagnostic de trouble
anxieux (n = 29) à ceux qui n'ont pas (n = 24) et à un groupe témoin avec un développement typique (TDC; n = 37).
Le groupe TSA et le groupe avec trouble anxieux ont montré une diminution du volume de l'amygdale
droite (contrôlée pour le volume total du cerveau) par rapport au groupe TSA sans anxiété (p = .04) et au groupe TDC (p = 0,08).
Les résultats suggèrent que les jeunes avec un diagnostic de TSA et d'anxiété
coexistante ont une trajectoire de développement neurologique distincte.
J Autism Dev Disord. 2017 Jul 8. doi: 10.1007/s10803-017-3206-1.
Amygdala Volume Differences in Autism Spectrum Disorder Are Related to Anxiety
Herrington JD1,2, Maddox BB3, Kerns CM4,5, Rump K6, Worley JA7, Bush JC8, McVey AJ9, Schultz RT3,6,10, Miller JS3,6.
Author information
- 1
- Center for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 860, Philadelphia, PA, 19104, USA. herringtonj@email.chop.edu.
- 2
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Philadelphia, PA, 19104, USA. herringtonj@email.chop.edu.
- 3
- Center for Autism Research, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 860, Philadelphia, PA, 19104, USA.
- 4
- AJ Drexel Autism Institute & Community Health & Prevention, School of Public Health, Drexel University, 3020 Market Street, Suite 560, Philadelphia, PA, 19104, USA.
- 5
- Center for Health Innovation, Adelphi University, Garden City, NY, 11530, USA.
- 6
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Philadelphia, PA, 19104, USA.
- 7
- SPIN Inc, 10521 Drummond Street, Philadelphia, PA, 19154, USA.
- 8
- Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th Street, Bloomington, IN, 47405, USA.
- 9
- Department of Psychology, Marquette University, PO Box 1881, Milwaukee, WI, 53233, USA.
- 10
- Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 860, Philadelphia, PA, 19104, USA.
Abstract
Recent
studies suggest that longstanding findings of abnormal amygdala
morphology in ASD may be related to symptoms of anxiety. To test this
hypothesis, fifty-three children with ASD (mean age = 11.9) underwent
structural MRI and were divided into subgroups to compare those with at
least one anxiety disorder
diagnosis (n = 29) to those without (n = 24) and to a typically
developing control group (TDC; n = 37). Groups were matched on age and
intellectual level. The ASD and anxiety group showed decreased right
amygdala volume (controlled for total brain volume) relative to ASD
without anxiety (p = .04) and TDCs (p = .068). Results suggest that
youth with ASD and co-occurring anxiety have a distinct
neurodevelopmental trajectory.
- PMID:28689329
- DOI:10.1007/s10803-017-3206-1
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