05 mai 2021

Une méta-analyse du microbiote intestinal chez les enfants autistes

Aperçu: G.M.

Des études antérieures ont rapporté une dysbiose dans le microbiote intestinal (MI) d'enfants avec un diagnostic du "trouble du spectre de l'autisme" (dTSA), qui peut être un facteur déterminant sur le développement de l'enfant à travers l'axe microbiote-intestin-cerveau. Cependant, on ne sait pas s'il existe un groupe spécifique de bactéries dysbiotiques dans les TSA. 


Le but de cette étude était de réaliser une méta-analyse sur les études qui analysent le MI chez les enfants avec un dTSA. 18 études remplissaient nos critères de sélection. 

Nos résultats ont montré une plus faible abondance relative de Streptococcus (SMD + = - 0,999; IC à 95% - 1,549, - 0,449) et de genres Bifidobacterium (SMD + = - 0,513; IC à 95% - 0,953, - 0,073) chez les enfants avec un dTSA. Dans l'ensemble, les genres Bifidobacterium sont impliqués. Cependant, les différences constatées entre les études sont attribuées à des facteurs tels que le biais de déclaration.

. 2021 May 5. doi: 10.1007/s10803-021-05002-y.

A Meta-analysis of Gut Microbiota in Children with Autism

Pedro Andreo-Martínez  1   2 , María Rubio-Aparicio  3 , Julio Sánchez-Meca  4 , Alejandro Veas  5 , Agustín Ernesto Martínez-González  6   7
Affiliations

Abstract

Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD+ = - 0.999; 95% CI - 1.549, - 0.449) and Bifidobacterium genera (SMD+ = - 0.513; 95% CI - 0.953, - 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.

Keywords: Autism spectrum disorders (ASD); Gut microbiota; Meta-analysis; Microbiota-gut-brain axis; Systematic review.

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