15 mai 2021

Exposition de la mère aux pesticides et risque de "troubles du spectre de l'autisme" chez la progéniture: une méta-analyse

Aperçu: G.M.

Cette méta-analyse a été menée pour estimer l'association globale entre l'exposition maternelle aux pesticides et le risque de TSA chez la progéniture.
Des rechertches ont été menées sur PubMed, EMBASE, Web of Science et PsycINFO jusqu'au 30 décembre 2020 pour inclure les études éligibles.
Huit études avec 50 426 participants, dont 5810 avaient un TSA, ont été impliquées dans l'étude.
Dans l'ensemble, le RC sommaire (intervalle de confiance à 95%) des TSA chez la progéniture pour l'exposition maternelle aux pesticides estimé par les mesures de proximité résidentielle et l'auto-évaluation était de 1,88 (1,10-3,20).
Cependant, l'exposition maternelle aux pesticides mesurée par des biomarqueurs n'était pas associée à un risque accru de TSA (OR combiné 1,13; IC à 95% 0,83-1,54).
D'autres études bien conçues sont nécessaires pour confirmer nos résultats.

  • 2021 May 12. doi: 10.1007/s10803-021-05063-z. 

Maternal Exposure to Pesticides and Risk of Autism Spectrum Disorders in Offspring: A Meta-analysis

Li Wang  1 , Shiming Tang  1 , Songjie Wu  2 , Lihua Yao  1 , Dezhen Su  1 , Ying Wang  3
Affiliations

Abstract

This meta-analysis was conducted to estimate the overall association between maternal exposure to pesticides and risk of ASD in offspring. PubMed, EMBASE, Web of Science, and the PsycINFO were searched until December 30, 2020 to include eligible studies. Eight studies with 50,426 participants, 5810 of whom had ASD, were involved in the study. Overall, the summary OR (95% confidence interval) of ASDs in offspring for maternal exposure to pesticide estimated by residential proximity measures and self-report was 1.88 (1.10-3.20). However, maternal exposure to pesticide measured by biomarkers was not associated with an increased risk of ASDs (pooled OR 1.13; 95% CI 0.83-1.54). Further well-designed studies are needed to confirm our findings.

Keywords: Autism; Meta-analysis; Pesticides; Risk factor.

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