Increased Risk of Autism Spectrum Disorders at Short and Long Interpregnancy Intervals in Finland

Traduction: G.M.

J Am Acad Child Adolesc Psychiatry. 2014 Oct;53(10):1074-1081.e4. doi: 10.1016/j.jaac.2014.06.009. Epub 2014 Aug 1.

Risque accru de troubles du spectre autistique avec des intervalles intergestationnels court et long en Finlande

Cheslack-Postava K¹, Suominen A², Jokiranta E², Lehti V², McKeague IW³, Sourander A⁴, Brown AS⁵.

Author information

• ¹Columbia University Mailman School of Public Health, New York. Electronic address: kc2497@columbia.edu
• ²University of Turku, Turku, Finland.
• ³Columbia University Mailman School of Public Health, New York.
• ⁴University of Turku, Turku, Finland; University Hospital of Turku; College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY.
• ⁵Columbia University Mailman School of Public Health, New York; College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY.

Abstract

OBJECTIVE:

Both short and long interpregnancy intervals (IPI) are believed to present possible adverse conditions for fetal development. Short IPI has recently been associated with increased risk of autism, but whether long IPI increases risk for autism spectrum disorders (ASD) has not been thoroughly investigated. We investigated the association between short and long IPI in a Finnish population-based study.
Les  deux intervalles intergestationnels courts et longs (IPI) sont soupçonnés de présenter des conditions défavorables possibles pour le développement du fœtus. L'IPI court a récemment été associée à un risque accru d'autisme, mais l'augmentation du risque de troubles du spectre autistique pour des IPI longs n'a pas été complètement étudiée. Nous avons étudié l'association entre court et long IPI dans une étude basée sur la population finlandaise.

METHOD:

This study was conducted in the Finnish Prenatal Study of Autism, which is based in a national birth cohort. Children born in Finland in 1987 to 2005 and diagnosed with ASD by 2007 were identified through the Finnish Hospital Discharge Register. A total of 2,208 non-firstborn patients with ASD and 5,163 matched controls identified from the Finnish Medical Birth Register were included in the primary analysis. The association between IPI and ASD was determined using conditional logistic regression and adjusted for potential confounders.

RESULTS

Relative to births with an IPI of 24 to 59 months, those with the shortest IPI (<12 months) had an increased risk of ASD (odds ratio [OR] = 1.50, 95% CI = 1.28, 1.74) in confounder-adjusted models, whereas the ORs for longer IPI births (60-119 months and ≥120 months) were 1.28 (95% CI = 1.08, 1.52) and 1.44 (95% CI = 1.12, 1.85), respectively.
Par rapport aux naissances avec un IPI de 24 à 59 mois, ceux qui ont les plus courts IPI (<12 mois) avaient un risque accru de TSA (odds ratio [OR] = 1,50, IC à 95% = 1,28, 1,74) dans les modèles confusionnelles ajustés , considérant que les ORs pour les longs intervalles entre naissances IPI (60-119 mois et ≥120 mois) étaient de 1,28 (IC à 95% = 1,08, 1,52) et de 1,44 (IC à 95% = 1,12, 1,85), respectivement.

CONCLUSION

This study provides evidence that risk of ASD is increased at long as well as short IPI.
Cette étude fournit la preuve que le risque de TSA est augmenté à tant à long qu'à court IPI.


Copyright © 2014 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

PMID: 25245351