Niveaux plasmatiques de chimiokines altérés dans l'autisme et leur association avec les comportements sociaux

Traduction partielle: G.M.

Psychiatry Res. 2016 Aug 2;244:300-305. doi: 10.1016/j.psychres.2016.07.057.

Altered plasma levels of chemokines in autism and their association with social behaviors

Shen Y¹, Oua J¹, Liu M¹, Shi L², Li Y¹, Xiao L¹, Dong H¹, Zhang F³, Xia K⁴, Zhao J⁵.

Author information

• ¹The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China.
• ²The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China; Neuropsychology and Applied Cognitive Neuroscience Research Group, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
• ³The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China; Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA.
• ⁴State Key Laboratory of Medical Genetics, Central South University, Changsha, China.
• ⁵The National Clinical Research Center for Mental Health Disorders, China; The National Technology Institute of Psychiatry, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, China; Institute of Mental Health, the Second Xiangya Hospital, Central South University, China; State Key Laboratory of Medical Genetics, Central South University, Changsha, China. Electronic address: zhaojingpingcsu@163.com

Abstract

Autism Spectrum Disorder (ASD) is a group of neurodevelopment disorders with an unclear etiology. Chemokines have been implicated in the etiology and pathogenesis of ASD. The current study investigated the plasma levels of seven chemokines (RANTES, Eotaxin, MIP-1 α, MIP-1 β, MCP-1, IP-10, and MIG) in 42 young autistic patients and 35 age-matched typically developing (TD) children. The study also tested the association between these chemokine levels and social behaviors, as measured by the Social Responsiveness Scale (SRS). Compared to the TD children, RANTES, MIP-1α, and MIP-1β were higher, while IP-10 and MIG were lower in the autistic patients, after correcting for multiple comparisons. Among these seven chemokines, MIP-1α, MIP-1β and IP-10 levels were found to be associated with social behaviors in all the participants. Moreover, MIP-1α and IP-10 were found to be independent predictors of social behaviors.
The results of our study support the hypothesis that altered chemokine levels are involved in the pathophysiology of ASD and they indicate that chemokines plasma levels could be potential biomarkers for ASD.
Les résultats de notre étude confirment l'hypothèse selon laquelle les niveaux modifiés de chimiokines sont impliqués dans la physiopathologie du TSA et ils indiquent que les niveaux de chimiokines plasmatiques pourraient être des biomarqueurs potentiels pour le TDA.
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PMID: 27512919

DOI: 10.1016/j.psychres.2016.07.057