Trouble hormonal et carence en vitamine dans le trouble du déficité d'attention avec hyperactivité (TDAH) et les troubles du spectre de l'autisme(TSA).

Traduction: G.M.

J Pediatr Endocrinol Metab. 2016 Aug 22. pii: /j/jpem.ahead-of-print/jpem-2015-0473/jpem-2015-0473.xml. doi: 10.1515/jpem-2015-0473.

Hormone disorder and vitamin deficiency in attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs)

Bala KA, Doğan M, Kaba S, Mutluer T, Aslan O, Doğan SZ.

Abstract

BACKGROUND:

The aim of this study was to analyze thyroid hormones and antibodies, ferritin, vitamins B12 and D, adrenal and gonadal steroid levels, and celiac antibodies in children diagnosed with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).
Le but de cette étude était d'analyser les hormones thyroïdiennes et les anticorps, la ferritine, les vitamines B12 et D, les niveaux de stéroïdes surrénales et ddes gonades, et des anticorps de la maladie coeliaque chez les enfants diagnostiqués avec un trouble déficitaire de l'attention avec hyperactivité (TDAH) et des troubles du spectre de l'autisme(TSA).

METHODS:

Between February 2014 and July 2014, a total of 77 children and adolescents (31 girls, 46 boys) who were admitted to the Van Training and Research Hospital were included in the study. The study population was divided into three groups including ADHD (n=34), ASD (n=16), and age- and sex-matched healthy controls (n=27). The diagnosis of ADHD was made on the basis of Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5) and DSM-4 Turkish version with the diagnostic interview and Disruptive Behavior Disorder Rating Scale (DBDRS). The diagnosis of ASD was based on the DSM-4 and DSM-5 Turkish version with the diagnostic interview and the Childhood Autism Rating Scale (CARS). The blood samples were obtained between 8:00 and 9:00 A.M.

RESULTS:

There was a statistically significant difference in vitamin B12 and D levels and ferritin values among the three groups. The ASD group had the highest ferritin and the lowest vitamins B12 and D levels. Vitamin D levels of the ADHD group were significantly lower compared to the healthy controls.
Il y avait une différence statistiquement significative dans les taux de vitamine B12 et D et les valeurs de ferritine entre les trois groupes. Le groupe TSA avaient des niveaux D le plus élevé de ferritine et la plus faible en vitamines B12 et. vitamine D du groupe TDAH étaient significativement plus faibles par rapport aux témoins sains.

CONCLUSIONS:

Our study results highlight the importance of supplementation of vitamins B12 and D in the ASD and ADHD patients.
Les résultats de notre étude mettent en évidence l'importance de la supplémentation en vitamines B12 et D chez les patients avec TSA et TDAH.

PMID: 27544717

DOI:10.1515/jpem-2015-0473