La polyarthrite rhumatoïde parentale et les "troubles du spectre de l'autisme" chez les descendants: une étude de cohorte nationale danoise

Aperçu: G.M.

La polyarthrite rhumatoïde maternelle (PR) a été associée à un risque accru de "trouble du spectre de l'autisme" (TSA) chez les descendants. Les chercheurs ont évalué l'influence potentielle de la PR maternelle et paternelle sur le risque de TSA chez la progéniture afin de démêler l'influence de l'hérédité génétique d'autres conditions pouvant mener à la programmation fœtale.L'étude de cohorte nationale a inclus tous les enfants nés vivants de 1977 à 2008 au Danemark (N = 1 917 723). Les modèles de régression de Cox ont été utilisés pour calculer les rapports de taux de risque (TS) de TSA de la progéniture exposée à la polyarthrite rhumatoïde maternelle ou paternelle, comparativement aux enfants non exposés.La PR maternelle était associée à un risque accru de TSA d'environ 30% chez la progéniture (HR = 1,31 et IC 95% = 1,06-1,63). De plus, la PR paternelle semblait augmenter le risque de TSA d'environ 30% (HR = 1,33, IC 95% = 0,97-1,82).Ces résultats suggèrent que la PR maternelle et paternelle soit associée à un risque accru de TSA chez la progéniture, indiquant que les facteurs génétiques associés à la PR peuvent également jouer un rôle dans l'étiologie du TSA chez les enfants de parents atteints de PR.

J Am Acad Child Adolesc Psychiatry. 2018 Jan;57(1):28-32.e1. doi: 10.1016/j.jaac.2017.10.002. Epub 2017 Oct 9.

Parental Rheumatoid Arthritis and Autism Spectrum Disorders in Offspring: A Danish Nationwide Cohort Study

Rom AL¹, Wu CS², Olsen J³, Jawaheer D⁴, Hetland ML⁵, Mørch LS⁶.

Author information

1

Research Unit Women's and Children's Health, The Juliane Marie Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. Electronic address: ane.lilleoere.rom@regionh.dk.

2

Research Unit of Gynecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense, and Odense University Hospital.

3

Section for Epidemiology, University of Aarhus, Aarhus, Denmark, and Fielding School of Public Health, University of California, Los Angeles.

4

Children's Hospital Oakland Research Institute, Oakland, CA.

5

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

6

Gynaecological Clinic, The Juliane Marie Centre, Copenhagen University Hospital, and Danish Cancer Society Research Centre, Virus, Lifestyle and Genes Unit, Copenhagen.

Abstract

OBJECTIVE:

Maternal rheumatoid arthritis (RA) has been associated with an increased risk of autism spectrum disorder (ASD) in the offspring. We assessed the potential influence of both maternal and paternal RA on the risk of ASD in offspring to disentangle the influence of genetic inheritance from other conditions potentially leading to fetal programming.

METHOD:

The nationwide cohort study included all children born alive from 1977 to 2008 in Denmark (N = 1,917,723). Cox regression models were used to calculate hazard rate ratios (HR) of ASD in offspring exposed to maternal or paternal RA, compared to unexposed children.

RESULTS:

Maternal RA was associated with an approximately 30% increased risk of ASD in the offspring (HR = 1.31 and 95% CI = 1.06-1.63). Also, paternal RA seemed to increase the risk of ASD by approximately 30% (HR = 1.33, 95% CI = 0.97-1.82).

CONCLUSION:

Our findings suggest maternal as well as paternal RA to be associated with an increased risk of ASD in the offspring, indicating that genetic factors associated with RA may also play a role in the etiology of ASD in children of parents with RA.

Copyright © 2017 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

 

PMID:29301665

DOI:10.1016/j.jaac.2017.10.002