Aperçu: G.M.
Les âges parentaux plus jeunes étaient généralement
associés à des taux accrus de psychopathologie des descendants. Après avoir contrôlé les caractéristiques socio-démographiques et la
comorbidité, les âges maternels et paternels plus jeunes ont été
associés à des syndromes de comportement et à une psychose chez les
jeunes, alors que l'âge paternel avancé était associé à des troubles du
développement / troubles du spectre de l'autisme.
Ces
résultats suggèrent que l'âge des parents plus jeune et plus âgé à la
naissance est associé à des formes spécifiques de psychopathologie chez
les descendants. La persistance de l'influence de l'âge parental après le contrôle des
facteurs démographiques et un indice de l'environnement social suggère nt
que des explications supplémentaires pour ces résultats devraient être
examinées dans les études futures.
J Am Acad Child Adolesc Psychiatry. 2017 May;56(5):391-400. doi: 10.1016/j.jaac.2017.02.004. Epub 2017 Mar 6.
Parental Age and Offspring Psychopathology in the Philadelphia Neurodevelopmental Cohort
Merikangas AK1, Calkins ME2, Bilker WB3, Moore TM2, Gur RC2, Gur RE2.
Author information
- 1
- Lifespan Brain Institute, Children's Hospital of Philadelphia and Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Electronic address: ameri@upenn.edu
- 2
- Lifespan Brain Institute, Children's Hospital of Philadelphia and Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
- 3
- Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Abstract
OBJECTIVE:
Increasing evidence implicates advanced paternal age at offspring birth in neuropsychiatric disorders. Advanced maternal age has also been associated with schizophrenia and other neurodevelopmental disorders, whereas younger maternal age has been linked with behavioral disorders. Few studies have considered the specificity of the associations with respect to comorbidity. In addition, most prior studies have been conducted in clinical samples or registries that may reflect more severe forms of psychopathology. The aim of this research is to examine the independent and joint associations of maternal and paternal age with specific subtypes of psychopathology in offspring in a pediatric sample of adolescents with emergent psychiatric syndromes.METHOD:
A total of 8,725 youths (aged 8-21 years) from the Philadelphia Neurodevelopmental Cohort were included in the analyses. Logistic regression models with parental age predicting offspring psychopathology were adjusted for sociodemographic factors and comorbid disorders.RESULTS:
We found that younger parental ages were generally associated with increased rates of offspring psychopathology. After controlling for sociodemographic characteristics and comorbidity, both younger maternal and paternal ages were associated with behavior syndromes and psychosis in youth, whereas advanced paternal age was associated with pervasive developmental disorders/autism spectrum disorder (PDD/ASD).CONCLUSION:
These findings suggest that both younger and older parental age at birth are associated with specific forms of psychopathology in offspring. The persistence of the influence of parental age after control for demographic factors and an index of social environment suggests that additional explanations for these findings should be examined in future studies.
Copyright © 2017 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
- PMID: 28433088
- DOI: 10.1016/j.jaac.2017.02.004
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