Aperçu: G.M.
Plusieurs
études suggèrent que les jeunes peuvent être particulièrement sensibles
à la neurotoxicité induite par la pollution atmosphérique et que
l'exposition périnatale peut causer ou contribuer à des troubles du
développement et des anomalies comportementales. En
particulier, un certain nombre d'études récentes ont trouvé des
associations entre les expositions à la pollution atmosphérique liée au
trafic et aux troubles du spectre de l'autisme.
Les
enfants autistes présentent des niveaux plus élevés de
neuroinflammation et d'inflammation systémique, qui sont également
caractéristiques de l'exposition à la pollution atmosphérique liée à la
circulation. Les
interactions génico-environnementales peuvent jouer un rôle important
dans la détermination de la susceptibilité individuelle à la
neurotoxicité développementale de la pollution atmosphérique.
Curr Environ Health Rep. 2017 Apr 17. doi: 10.1007/s40572-017-0135-2.
Developmental Neurotoxicity of Traffic-Related Air Pollution: Focus on Autism
Author information
- 1
- Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt, Suite No. 100, Seattle, WA, 98105, USA. lgcosta@u.washington.edu
- 2
- Department of Neuroscience, University of Parma, Parma, Italy. lgcosta@u.washington.edu.
- 3
- Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt, Suite No. 100, Seattle, WA, 98105, USA.
- 4
- Center on Human Development and Disability, University of Washington, Seattle, WA, USA.
Abstract
PURPOSE OF REVIEW:
Epidemiological and animal studies suggest that air pollution may negatively affect the central nervous system (CNS) and contribute to CNS diseases. Traffic-related air pollution is a major contributor to global air pollution, and diesel exhaust (DE) is its most important component.RECENT FINDINGS:
Several studies suggest that young individuals may be particularly susceptible to air pollution-induced neurotoxicity and that perinatal exposure may cause or contribute to developmental disabilities and behavioral abnormalities. In particular, a number of recent studies have found associations between exposures to traffic-related air pollution and autism spectrum disorders (ASD), which are characterized by impairment in socialization and in communication and by the presence of repetitive and unusual behaviors. The cause(s) of ASD are unknown, and while it may have a hereditary component, environmental factors are increasingly suspected as playing a pivotal role in its etiology, particularly in genetically susceptible individuals. Autistic children present higher levels of neuroinflammation and systemic inflammation, which are also hallmarks of exposure to traffic-related air pollution. Gene-environment interactions may play a relevant role in determining individual susceptibility to air pollution developmental neurotoxicity. Given the worldwide presence of elevated air pollution, studies on its effects and mechanisms on the developing brain, genetic susceptibility, role in neurodevelopmental disorders, and possible therapeutic interventions are certainly warranted.- PMID: 28417440
- DOI: 10.1007/s40572-017-0135-2
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