Une étude spectroscopique de résonance magnétique du proton dans le trouble du spectre de l'autisme utilisant un système d'imagerie par résonance magnétique clinique 3-Tesla (IRM): le cortex cingulaire antérieur gauche et le cervelet

Aperçu: G.M.

La pathophysiologie du trouble du spectre de l'autisme (TSA) n'est pas entièrement comprise. Cette étude a utilisé la spectroscopie de résonance magnétique proton pour étudier les rapports de concentration des métabolites dans le cortex cingulaire antérieur et le cervelet gauche dans le TSA.

Les sujets avec un diagnostic de TSA ont des altérations hypoGABAergiques dans le cortex cingulaire antérieur et des hyperglutamatères / hypoGABAergiques dans le cervelet gauche. 

J Child Neurol. 2017 Jan 1:883073817702981. doi: 10.1177/0883073817702981.

A Proton Magnetic Resonance Spectroscopic Study in Autism Spectrum Disorder Using a 3-Tesla Clinical Magnetic Resonance Imaging (MRI) System: The Anterior Cingulate Cortex and the Left Cerebellum

Ito H^1,2, Mori K³, Harada M⁴, Hisaoka S⁴, Toda Y², Mori T², Goji A², Abe Y², Miyazaki M², Kagami S².

Author information

1

1 Department of Special Needs Education, Graduate School of Education, Naruto University of Education, Tokushima, Japan.

2

2 Department of Pediatrics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

3

3 Department of Child Health & Nursing, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

4

4 Department of Radiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

Abstract

The pathophysiology of autism spectrum disorder (ASD) is not fully understood. We used proton magnetic resonance spectroscopy to investigate metabolite concentration ratios in the anterior cingulate cortex and left cerebellum in ASD. In the ACC and left cerebellum studies, the ASD group and intelligence quotient- and age-matched control group consisted of 112 and 114 subjects and 65 and 45 subjects, respectively. In the ASD group, γ-aminobutyric acid (GABA)+/ creatine/phosphocreatine (Cr) was significantly decreased in the anterior cingulate cortex, and glutamate (Glu)/Cr was significantly increased and GABA+/Cr was significantly decreased in the left cerebellum compared to those in the control group. In addition, both groups showed negative correlations between Glu/Cr and GABA+/Cr in the left cerebellum, and positive correlations between GABA+/Cr in the anterior cingulate cortex and left cerebellum. ASD subjects have hypoGABAergic alterations in the anterior cingulate cortex and hyperglutamatergic/hypoGABAergic alterations in the left cerebellum.

PMID: 28420309

DOI: 10.1177/0883073817702981