Réseaux de neurones de l'oxotine et de la vasopressine: implications pour la diversité sociale du comportement et la neuroscience translationnelle

Aperçu: G.M.

Les systèmes liés à l'oxytocine et à la vasopressine sont présents chez les animaux invertébrés et vertébrés, y compris les humains, et présentent des propriétés neuroanatomiques et fonctionnelles conservées. Chez les vertébrés, ces systèmes inervent des réseaux de neurones conservés qui régulent l'apprentissage social et le comportement, y compris la reconnaissance conspécifique, l'attachement social et le comportement des parents.

L'étude décrit les caractéristiques conservées et variables des systèmes centraux d'ocytocine et de vasopressine dans le contexte de la diversité sociale du comportement, en mettant particulièrement l'accent sur les réseaux neuronaux qui modulent l'apprentissage social, le comportement et la souplesse des stimulants socio-sensoriels dans les contextes sociaux typiques des espèces. 

Neurosci Biobehav Rev. 2017 May;76(Pt A):87-98. doi: 10.1016/j.neubiorev.2017.01.034.

Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience

Johnson ZV¹, Young LJ².

Author information

1

Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: zjohnso2@gmail.com

2

Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Electronic address: lyoun03@emory.edu.

Abstract

Oxytocin- and vasopressin-related systems are present in invertebrate and vertebrate bilaterian animals, including humans, and exhibit conserved neuroanatomical and functional properties. In vertebrates, these systems innervate conserved neural networks that regulate social learning and behavior, including conspecific recognition, social attachment, and parental behavior. Individual and species-level variation in central organization of oxytocin and vasopressin systems has been linked to individual and species variation in social learning and behavior. In humans, genetic polymorphisms in the genes encoding oxytocin and vasopressin peptides and/or their respective target receptors have been associated with individual variation in social recognition, social attachment phenotypes, parental behavior, and psychiatric phenotypes such as autism. Here we describe both conserved and variable features of central oxytocin and vasopressin systems in the context of social behavioral diversity, with a particular focus on neural networks that modulate social learning, behavior, and salience of sociosensory stimuli during species-typical social contexts.

Published by Elsevier Ltd.

PMID: 28434591

DOI: 10.1016/j.neubiorev.2017.01.034