Groupe de niveaux de différenciation 5 (CD5) dans le plasma des enfants avec un diagnostic de trouble du spectre de l'autisme (TSA)

Aperçu: G.M.

Les taux de CD5 ont été déterminés dans le plasma de trente et un  participant utilisant un dosage classés comme léger-modérés et sévères selon leurs scores au CARS et comparé à trente-trois participants du groupe contrôle appariés selon l'âge et le sexe. 

Les données préliminaires indiquent que les enfants avec un diagnostic de TSA et un score CARS élevé (n = 12) ont montré significativement (p = 0,02) un taux plasmatique plus élevé de CD5  que ceux les enfants du groupe contrôle et que les enfants avec un diagnostic de TSA et un score CARS faible. Cependant, il n'y avait pas de différence significative entre les niveaux de CD5 chez les ces enfants et les enfants témoins. 

Le diagnostic des enfants autistes est fondé sur la base du score CARS > 30.  

J Coll Physicians Surg Pak. 2017 Mar;27(3):149-152. doi: 2575.

Cluster of Differentiation 5 (CD5) Levels in the Plasma of Children with Autism Spectrum Disorder (ASD)

Halepoto DM¹, Alhowikan AM², Ayadhi LA¹.

Author information

1

Autism Research and Treatment Center, Al-Amodi Autism Research Chair, King Saud University, Riyadh-11461, Saudi Arabia.

2

Autism Research and Treatment Center, Al-Amodi Autism Department of Physiology, Faculty of Medicine, King Saud University, Riyadh-11461, Saudi Arabia.

Abstract

OBJECTIVE:

To investigate the cluster of differentiation 5 (CD5) plasma levels and their association with childhood autism rating scale (CARS) in subjects with autism spectrum disorder (ASD) compared to age and gender matched healthy controls, and to explore the link between CD5, severity, and autoimmunity in autism.

STUDY DESIGN:

Case-control study.

PLACE AND DURATION OF STUDY:

Autism Research and Treatment Center, Al-Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, from October 2014 to May 2015.

METHODOLOGY:

CD5 levels were determined in the plasma of thirty-one (31) patients using enzyme-linked immunosorbent assay (ELISA), categorized as mild-moderate and severe as indicated by their Childhood Autism Rating Scale (CARS) score and compared to thirty-three (33) age and gender-matched control samples.

RESULTS:

The preliminary data indicated that children with severe autism (n=12), exhibited significantly (p=0.02) higher plasma level of CD5 [0.55 (0.14-12) pg/ml {median (interquartile range=IQR)}] than those of normal controls [n=33, 0.29 (0.08-0.79) pg/ml {median (IQR)}] and children with mild to moderate autism [n=19, 0.26 (0.13-1.42) pg/ml, {median (IQR)}, p=0.08]. However, there was no significant difference between the CD5 levels of children with mild to moderate autism and normal controls (p = 0.62). Diagnoses of autistic children based on the CARS score >30. Disease severity and the CARS score, which represent stereotyped patterns of behavior in children with autism, were positively correlated (r = 0.43, p = 0.02).

CONCLUSION:

The high CD5 plasma levels in patients with severe ASD, probably indicated that CD5 might be implicated in the physiology of autism. However, this finding should be treated with caution until further investigations are performed with larger populations to determine whether the increase in plasma CD5 levels is a mere consequence of autism or it plays a pathogenic role in the disease.

PMID: 28406773

DOI: 2575