24 avril 2017

L'âge paternel altère le développement social chez les descendants

Aperçu: G.M.
L'âge paternel avancé (APA) à la conception a été lié à l'autisme et à la schizophrénie dans les progénitures.
Dans la population générale, les âges paternels très jeunes et avancés ont été tous deux associés à une trajectoire modifiée du développement social

J Am Acad Child Adolesc Psychiatry. 2017 May;56(5):383-390. doi: 10.1016/j.jaac.2017.02.006. Epub 2017 Mar 6.

Paternal Age Alters Social Development in Offspring

Author information

1
Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, UK; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York. Electronic address: magdalena.janecka@mssm.edu.
2
MRC Integrative Epidemiology Unit, School of Experimental Psychology and School of Social and Community Medicine, University of Bristol, UK.
3
Birkbeck University of London, UK.
4
Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, UK.
5
Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, UK; University of Exeter Medical School, University of Exeter, Exeter, UK.
6
School of Biological Sciences, University of Essex, Colchester, UK.
7
Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York.

Abstract

OBJECTIVE:

Advanced paternal age (APA) at conception has been linked with autism and schizophrenia in offspring, neurodevelopmental disorders that affect social functioning. The current study explored the effects of paternal age on social development in the general population.

METHOD:

We used multilevel growth modeling to investigate APA effects on socioemotional development from early childhood until adolescence, as measured by the Strengths and Difficulties Questionnaire (SDQ) in the Twins Early Development Study (TEDS) sample. We also investigated genetic and environmental underpinnings of the paternal age effects on development, using the Additive genetics, Common environment, unique Environment (ACE) and gene-environment (GxE) models.

RESULTS:

In the general population, both very young and advanced paternal ages were associated with altered trajectory of social development (intercept: p = .01; slope: p = .03). No other behavioral domain was affected by either young or advanced age at fatherhood, suggesting specificity of paternal age effects. Increased importance of genetic factors in social development was recorded in the offspring of older but not very young fathers, suggesting distinct underpinnings of the paternal age effects at these two extremes.

CONCLUSION:

Our findings highlight that the APA-related deficits that lead to autism and schizophrenia are likely continuously distributed in the population.
PMID: 28433087
DOI: 10.1016/j.jaac.2017.02.006

Aucun commentaire: