Aperçu: G.M.
L'ocytocine peut influencer divers comportements humains et la connectivité à travers les réseaux sous-corticaux et corticaux.
Une
analyse indépendante de l'expression du gène du récepteur de
l'ocytocine (OXTR) dans les zones subcorticales et corticales humaines a
été réalisée pour déterminer la plausibilité des effets directs de
l'ocytocine sur l'OXTR.
Chez
les femmes, l'OXTR a été fortement exprimé dans les régions striatées
et autres sous-corticales, mais a montré une expression modeste dans les
zones corticales. L'ocytocine
a augmenté la connectivité entre les circuits corticostriatals
généralement impliqués dans la récompense, l'émotion, la communication
sociale, le traitement de la langue et de la douleur. Cet effet a été de 1,39 écart-type au-dessus de l'effet nul d'une différence entre l'ocytocine et le placebo. Cet
effet lié à l'ocytocine sur la connectivité corticostriatale covalente
avec des traits autistiques, de sorte que l'augmentation de la
connectivité associée à l'ocytocine était plus forte chez les personnes
ayant des caractères autistiques plus élevés. En
résumé, l'ocytocine a renforcé la connectivité corticostriatale chez
les femmes, en particulier avec les réseaux corticaux impliqués dans les
processus social-communicatifs, motivants et affectifs.
Transl Psychiatry. 2017 Apr 18;7(4):e1099. doi: 10.1038/tp.2017.72.
Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women
Bethlehem RAI1, Lombardo MV1,2, Lai MC1,3,4, Auyeung B1,5, Crockford SK1, Deakin J6,7, Soubramanian S6,8, Sule A6, Kundu P9,10, Voon V6,7,8,11, Baron-Cohen S1,12.
Author information
- 1
- Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK.
- 2
- Department of Psychology, Center for Applied Neuroscience, University of Cyprus, Nicosia, Cyprus.
- 3
- Department of Psychiatry, Child and Youth Mental Health Collaborative at the Centre for Addiction and Mental Health and The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
- 4
- Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
- 5
- Department of Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK.
- 6
- Department of Psychiatry, University of Cambridge, Cambridge, UK.
- 7
- Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
- 8
- Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
- 9
- Brain Imaging Center, Icahn Institute of Medicine at Mt. Sinai, New York, NY, USA.
- 10
- Translational and Molecular Imaging Institute, Icahn Institute of Medicine at Mt. Sinai, New York, NY, USA.
- 11
- National Institute for Health Research Biomedical Research Council, University of Cambridge, Cambridge, UK.
- 12
- CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Abstract
Oxytocin
may influence various human behaviors and the connectivity across
subcortical and cortical networks. Previous oxytocin studies are male
biased and often constrained by task-based inferences. Here, we
investigate the impact of oxytocin on resting-state connectivity between
subcortical and cortical networks in women. We collected resting-state
functional magnetic resonance imaging (fMRI) data on 26 typically
developing women 40 min following intranasal oxytocin administration
using a double-blind placebo-controlled crossover design. Independent
components analysis (ICA) was applied to examine connectivity between
networks. An independent analysis of oxytocin receptor (OXTR) gene
expression in human subcortical and cortical areas was carried out to
determine plausibility of direct oxytocin effects on OXTR. In women,
OXTR was highly expressed in striatal and other subcortical regions, but
showed modest expression in cortical areas. Oxytocin increased
connectivity between corticostriatal circuitry typically involved in
reward, emotion, social communication, language and pain processing.
This effect was 1.39 standard deviations above the null effect of no
difference between oxytocin and placebo. This oxytocin-related effect on
corticostriatal connectivity covaried with autistic traits, such that
oxytocin-related increase in connectivity was stronger in individuals
with higher autistic traits. In sum, oxytocin strengthened
corticostriatal connectivity in women, particularly with cortical
networks that are involved in social-communicative, motivational and
affective processes. This effect may be important for future work on
neurological and psychiatric conditions (for example, autism),
particularly through highlighting how oxytocin may operate differently
for subsets of individuals.
- PMID: 28418398
- DOI: 10.1038/tp.2017.72
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