Aperçu: G.M.
Un corpus callosum épais (TCC) peut être associé à un résultat très
grave chez les fœtus, mais sa présentation clinique chez les enfants
plus âgés semble nettement différente.
Sur 2.552 images d'IRM cérébrales, celles de 37 enfants ont d'abord été considérées comme montrant une TCC. L'imagerie
initiale a été examinée par un neuroradiologue expérimenté, qui a
confirmé le diagnostic chez 34 enfants (1,3%): 13 avaient une
neurofibromatose-1 (NF-1), 9 avaient une épilepsie, 3 avaient un
syndrome de malformation capillaire macrocéphalique (MCM), 3 avaient un trouble du spectre de l'autisme, 1 avait une malformation Chiari-1 et 1 avait une circonférence croisée accrue. Aucun trouble neurologique spécifique ne peut être défini chez sept enfants. Un
TCC est une malformation rare du cerveau qui peut être trouvée dans les
neuropathologies avec des mécanismes pathognomoniques apparemment
divers, tels que NF-1 et MCM. Ce n'est pas nécessairement associé à des conditions de vie en danger,
mais plutôt une découverte relativement bénigne, de nature différente
de celle rapportée chez les fœtus.
J Clin Neurol. 2017 Apr;13(2):170-174. doi: 10.3988/jcn.2017.13.2.170.
Thick Corpus Callosum in Children
Author information
- 1
- Department of Pediatric Neurology and Epilepsy Center, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
- 2
- Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
- 3
- Department of Radiology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
- 4
- Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. savinoam@013.net.
Abstract
BACKGROUND AND PURPOSE:
A thick corpus callosum (TCC) can be associated with a very grave outcome in fetuses, but its clinical presentation in older children seems to be markedly different.METHODS:
The corpus callosum (CC) was defined as thick based on observations and impressions. We reviewed cases of children who were diagnosed as TCC based on brain magnetic resonance imaging (MRI) studies. The pertinent clinical data of these children were collected, and their CCs were measured.RESULTS:
Out of 2,552 brain MRI images, those of 37 children were initially considered as showing a TCC. Those initial imaging were reviewed by an experienced neuroradiologist, who confirmed the diagnosis in 34 children (1.3%): 13 had neurofibromatosis-1 (NF-1), 9 had epilepsy, 3 had macrocephaly capillary malformation (MCM) syndrome, 3 had autistic spectrum disorder, 1 had a Chiari-1 malformation, and 1 had increased head circumference. No specific neurologic disorder could be defined in seven children. The measured thickness of the CC in these children was comparable to those published in the literature for adults.CONCLUSIONS:
A TCC is a rare brain malformation that can be found in neuropathologies with apparently diverse pathognomonic mechanisms, such as NF-1 and MCM. It is not necessarily associated with life-threatening conditions, instead being a relatively benign finding, different in nature from that reported in fetuses.- PMID: 28406584
- DOI: 10.3988/jcn.2017.13.2.170
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