Aperçu: G.M.
Un fonctionnement immunitaire altéré a été démontré chez les personnes avec un diagnostic de trouble du spectre de l'autisme (TSA). L'étude
actuelle explore la relation entre le fonctionnement immunitaire perçu
et l'expérience des traits de TSA chez les jeunes adultes en bonne
santé.
Une
corrélation négative significative a été trouvée entre le
fonctionnement immunitaire perçu et la sous-échelle AQ "difficultés avec
le changement.
Chez
les femmes, le fonctionnement immunitaire perçu de 1 élément est
significativement corrélé avec les sous-échelles AQ "difficultés avec le
changement" et "communication".
Chez
les hommes, aucune des sous-échelles AQ n'a été significativement
corrélée avec le fonctionnement immunitaire perçu d'un élément.
Int J Environ Res Public Health. 2017 Apr 12;14(4). pii: E409. doi: 10.3390/ijerph14040409.
Differential Gender Effects in the Relationship between Perceived Immune Functioning and Autistic Traits
Mackus M1, Kruijff D2, Otten LS3, Kraneveld AD4,5, Garssen J6,7, Verster JC8,9,10.
Author information
- 1
- Division of Pharmacology, Utrecht University, 3584 CG Utrecht, The Netherlands. m.mackus@uu.nl
- 2
- Division of Pharmacology, Utrecht University, 3584 CG Utrecht, The Netherlands. deborahdekruijff@gmail.com.
- 3
- Division of Pharmacology, Utrecht University, 3584 CG Utrecht, The Netherlands. l.s.otten@students.uu.nl.
- 4
- Division of Pharmacology, Utrecht University, 3584 CG Utrecht, The Netherlands. a.d.kraneveld@uu.nl.
- 5
- Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584 CS Utrecht, The Netherlands. a.d.kraneveld@uu.nl.
- 6
- Division of Pharmacology, Utrecht University, 3584 CG Utrecht, The Netherlands. j.garssen@uu.nl.
- 7
- Nutricia Research, 3584 CT Utrecht, The Netherlands. j.garssen@uu.nl.
- 8
- Division of Pharmacology, Utrecht University, 3584 CG Utrecht, The Netherlands. j.c.verster@uu.nl.
- 9
- Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584 CS Utrecht, The Netherlands. j.c.verster@uu.nl.
- 10
- Centre for Human Psychopharmacology, Swinburne University, Melbourne 3122, Australia. j.c.verster@uu.nl.
Abstract
Altered immune functioning has been demonstrated in individuals with autism spectrum disorder
(ASD). The current study explores the relationship between perceived
immune functioning and experiencing ASD traits in healthy young adults. N
= 410 students from Utrecht University completed a survey on immune
functioning and autistic
traits. In addition to a 1-item perceived immune functioning rating,
the Immune Function Questionnaire (IFQ) was completed to assess
perceived immune functioning. The Dutch translation of the Autism-Spectrum Quotient (AQ) was completed to examine variation in autistic
traits, including the domains "social insights and behavior",
"difficulties with change", "communication", "phantasy and imagination",
and "detail orientation". The 1-item perceived immune functioning score
did not significantly correlate with the total AQ score. However, a
significant negative correlation was found between perceived immune
functioning and the AQ subscale "difficulties with change" (r = -0.119, p
= 0.019). In women, 1-item perceived immune functioning correlated
significantly with the AQ subscales "difficulties with change" (r =
-0.149, p = 0.029) and "communication" (r = -0.145, p =
0.032). In men, none of the AQ subscales significantly correlated with
1-item perceived immune functioning. In conclusion, a modest
relationship between perceived immune functioning and several autistic traits was found.
- PMID: 28417950
- DOI: 10.3390/ijerph14040409
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