Déficit gestationnelle en vitamine D et trouble du spectre de l'autisme

Aperçu: G.M.

Le but de l'étude est de déterminer l'association entre le statut gestationnel de la vitamine D et le TSA. 

La déficience en vitamine D à mi-gestation était associée à un risque accru de TSA. Parce que la carence en vitamine D gestationnelle est facilement évitable avec une supplémentation sûre, peu coûteuse et facilement disponible, ce facteur de risque pourrait être évité.

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BJPsych Open. 2017 Apr 10;3(2):85-90. doi: 10.1192/bjpo.bp.116.004077. eCollection 2017.

Gestational vitamin D deficiency and autism spectrum disorder

Vinkhuyzen AAE¹, Eyles DW², Burne THJ², Blanken LME³, Kruithof CJ⁴, Verhulst F⁵, White T⁵, Jaddoe VW⁶, Tiemeier H⁷, McGrath JJ⁸.

Author information

1

, PhD, Queensland Brain Institute, The University of Queensland, St Lucia, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.

2

, PhD, Queensland Brain Institute, The University of Queensland, St Lucia, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia.

3

, MD, MSc, The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

4

, MSc, The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

5

, MD, PhD, Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

6

, MD, PhD, The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.

7

, MD, PhD, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

8

, MD, PhD, Queensland Brain Institute, The University of Queensland, St Lucia, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia.

Abstract

BACKGROUND:

There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood.

AIMS:

To determine the association between gestational vitamin D status and ASD.

METHOD:

Based on a birth cohort (n=4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid-gestation sera and neonatal sera, and ASD (defined by clinical records; n=68 cases).

RESULTS:

Individuals in the 25OHD-deficient group at mid-gestation had more than twofold increased risk of ASD (odds ratio (OR)=2.42, 95% confidence interval (CI) 1.09 to 5.07, P=0.03) compared with the sufficient group. The findings persisted in analyses including children of European ethnicity only.

CONCLUSIONS:

Mid-gestational vitamin D deficiency was associated with an increased risk of ASD. Because gestational vitamin D deficiency is readily preventable with safe, inexpensive and readily available supplementation, this risk factor warrants closer scrutiny.

DECLARATION OF INTEREST:

None.

COPYRIGHT AND USAGE:

© The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

PMID: 28446959

PMCID: PMC5385921

DOI: 10.1192/bjpo.bp.116.004077