La corrélation entre les concentrations d'ocytocine centrale et périphérique: un examen systématique et une méta-analyse

Aperçu: G.M.

Les résultats indiquent une coordination de la libération d'oxytocine centrale et périphérique après le stress et après administration intranasale. Bien que populaire, l'approche consistant à utiliser des niveaux d'ocytocine périphériques pour se rapprocher des niveaux centraux dans des conditions basales n'est pas justifiée par les résultats actuels.

Neurosci Biobehav Rev. 2017 Apr 22. pii: S0149-7634(17)30144-6. doi: 10.1016/j.neubiorev.2017.04.017.

The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis

Valstad M¹, Alvares GA², Egknud M³, Matziorinis AM¹, Andreassen OA³, Westlye LT¹, Quintana DS⁴.

Author information

1

NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway.

2

Telethon Kids Institute, University of Western Australia, Australia; Cooperative Research Centre for Living with Autism (Autism CRC), Long Pocket, Brisbane, Australia.

3

NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway.

4

NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway. Electronic address: daniel.quintana@medisin.uio.no

Abstract

There is growing interest in the role of the oxytocin system in social cognition and behavior. Peripheral oxytocin concentrations are regularly used to approximate central concentrations in psychiatric research, however, the validity of this approach is unclear. Here we conducted a pre-registered systematic search and meta-analysis of correlations between central and peripheral oxytocin concentrations. A search of databases yielded 17 eligible studies, resulting in a total sample size of 516 participants and subjects. Overall, a positive association between central and peripheral oxytocin concentrations was revealed [r=0.29, 95% CI (0.14, 0.42), p<0.0001]. This association was moderated by experimental context [Q_b(4), p=0.003]. While no association was observed under basal conditions (r=0.08, p=0.31), significant associations were observed after intranasal oxytocin administration (r=0.66, p<.0001), and after experimentally induced stress (r=0.49, p=0.0011). These results indicate a coordination of central and peripheral oxytocin release after stress and after intranasal administration. Although popular, the approach of using peripheral oxytocin levels to approximate central levels under basal conditions is not supported by the present results.

Copyright © 2017 Elsevier Ltd. All rights reserved.

PMID: 28442403

DOI: 10.1016/j.neubiorev.2017.04.017